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v1.0.0
ICD-10 Guide
ICD-10 CodesD84.81

D84.81

Billable

Immunodeficiency due to conditions classified elsewhere

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D84.81 is a billable code used to indicate a diagnosis of immunodeficiency due to conditions classified elsewhere.

Key Diagnostic Point:

Immunodeficiency due to conditions classified elsewhere (D84.81) refers to a state of immune system dysfunction that arises as a consequence of other underlying medical conditions. This can include a variety of hematologic disorders such as leukemias, lymphomas, and aplastic anemia, which can impair the body's ability to mount an effective immune response. Patients with these conditions often experience recurrent infections, prolonged illness, and complications due to their compromised immune systems. The immunodeficiency may be secondary to the disease process itself or as a result of treatments such as chemotherapy or immunosuppressive therapy. Accurate coding of D84.81 is essential for proper patient management and reimbursement, as it highlights the need for careful monitoring and potential interventions to prevent infections and manage complications associated with the underlying conditions. Clinicians must document the specific underlying condition leading to the immunodeficiency to ensure appropriate coding and treatment planning.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Requires knowledge of underlying conditions that lead to immunodeficiency.
  • Differentiation from primary immunodeficiencies.
  • Need for comprehensive documentation of the primary condition.
  • Potential for multiple co-existing conditions complicating coding.

Audit Risk Factors

  • Inadequate documentation of the underlying condition.
  • Failure to link immunodeficiency to the primary diagnosis.
  • Misclassification of primary versus secondary immunodeficiency.
  • Inconsistent coding practices across different providers.

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed clinical notes on the hematologic condition, treatment regimens, and any complications.

Common Clinical Scenarios

Patients with leukemia undergoing chemotherapy experiencing recurrent infections.

Billing Considerations

Ensure that all relevant laboratory results and treatment plans are documented to support the diagnosis.

Infectious Disease

Documentation Requirements

Thorough documentation of infections, treatment responses, and any prophylactic measures taken.

Common Clinical Scenarios

Patients with HIV/AIDS presenting with opportunistic infections.

Billing Considerations

Document the relationship between the immunodeficiency and the infections to support coding.

Coding Guidelines

Inclusion Criteria

Use D84.81 When
  • According to ICD
  • 10 coding guidelines, D84
  • 81 should be used when the immunodeficiency is a direct result of another condition
  • Coders must ensure that the primary condition is documented and coded first, followed by D84
  • 81 to indicate the immunodeficiency

Exclusion Criteria

Do NOT use D84.81 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

36415CPT Code

Collection of venous blood by venipuncture

Clinical Scenario

Used for laboratory tests to assess immune function in patients with D84.81.

Documentation Requirements

Document the reason for blood collection and any relevant clinical history.

Specialty Considerations

Hematologists should ensure that the rationale for testing is clearly stated.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of immunodeficiencies, enabling better tracking of conditions and outcomes. D84.81 provides a clear designation for immunodeficiency due to other conditions, improving the accuracy of patient records and reimbursement processes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of immunodeficiencies, enabling better tracking of conditions and outcomes. D84.81 provides a clear designation for immunodeficiency due to other conditions, improving the accuracy of patient records and reimbursement processes.

Reimbursement & Billing Impact

reimbursement processes.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

When should I use D84.81?

Use D84.81 when documenting immunodeficiency that is a direct result of another condition, ensuring that the underlying condition is also coded.