Mast cell activation, unspecified
ICD-10 D89.40 is a billable code used to indicate a diagnosis of mast cell activation, unspecified.
Mast cell activation syndrome (MCAS) is characterized by the inappropriate activation of mast cells, leading to the release of mediators such as histamine, cytokines, and other inflammatory substances. This condition can result in a variety of symptoms affecting multiple organ systems, including the skin, gastrointestinal tract, respiratory system, and cardiovascular system. Patients may present with symptoms such as flushing, urticaria, abdominal pain, diarrhea, and anaphylaxis. The unspecified nature of this code indicates that the specific triggers or underlying causes of mast cell activation have not been clearly identified. The condition can be challenging to diagnose due to its overlap with other allergic and non-allergic disorders, and it often requires a thorough clinical history, physical examination, and sometimes laboratory testing to rule out other conditions. Management typically involves the use of antihistamines, mast cell stabilizers, and avoidance of known triggers. Given the complexity of symptoms and potential for severe reactions, accurate coding is essential for appropriate treatment and reimbursement.
Detailed patient history, including symptom triggers and response to treatments.
Patients presenting with recurrent anaphylaxis or unexplained allergic symptoms.
Ensure thorough documentation of all symptoms and any diagnostic tests performed.
Documentation of any hematologic manifestations or complications related to mast cell activation.
Patients with mast cell activation presenting with hematologic abnormalities such as eosinophilia.
Consideration of co-existing hematologic disorders that may influence treatment.
Used to identify specific allergens in patients with suspected mast cell activation.
Document the specific allergens tested and patient reactions.
Allergy specialists should ensure comprehensive testing to rule out other conditions.
Common symptoms include flushing, hives, abdominal pain, diarrhea, and respiratory distress. Symptoms can vary widely among individuals.
Diagnosis typically involves a detailed patient history, physical examination, and laboratory tests such as serum tryptase levels to assess mast cell activity.
