Idiopathic mast cell activation syndrome
ICD-10 D89.42 is a billable code used to indicate a diagnosis of idiopathic mast cell activation syndrome.
Idiopathic mast cell activation syndrome (IMCAS) is a hematologic condition characterized by recurrent episodes of mast cell activation without an identifiable cause. Patients may experience a range of symptoms, including flushing, abdominal pain, diarrhea, and anaphylaxis-like reactions. The condition is often associated with an increase in mast cells in the bone marrow and other tissues, leading to the release of mediators such as histamine and cytokines. Diagnosis is typically made through clinical evaluation, symptom history, and sometimes bone marrow biopsy to assess mast cell proliferation. IMCAS can significantly impact the quality of life due to its unpredictable nature and the potential for severe allergic reactions. Management often involves the use of antihistamines, mast cell stabilizers, and avoidance of known triggers. Understanding the complexities of IMCAS is crucial for accurate coding and appropriate patient management.
Detailed patient history, symptom diary, and results from allergy testing.
Patients presenting with recurrent anaphylaxis or unexplained allergic symptoms.
Ensure documentation reflects the idiopathic nature and excludes other conditions.
Bone marrow biopsy results, mast cell counts, and clinical symptom correlation.
Patients with elevated mast cell levels and unexplained symptoms.
Document the rationale for bone marrow biopsy and any findings related to mast cell proliferation.
Used to evaluate mast cell levels and rule out other hematologic conditions.
Document the reason for the CBC and any abnormal findings.
Allergy and Immunology specialists should correlate CBC results with clinical symptoms.
Common symptoms include flushing, abdominal pain, diarrhea, fatigue, and anaphylaxis-like reactions. Symptoms can vary widely among individuals.
