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ICD-10 Guide
ICD-10 CodesE04.1

E04.1

Billable

Nontoxic single thyroid nodule

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 E04.1 is a billable code used to indicate a diagnosis of nontoxic single thyroid nodule.

Key Diagnostic Point:

A nontoxic single thyroid nodule is a localized growth within the thyroid gland that does not produce excess thyroid hormones and is not associated with hyperthyroidism. These nodules are often discovered incidentally during imaging studies or physical examinations. The majority of thyroid nodules are benign, with a small percentage being malignant. Risk factors for thyroid nodules include iodine deficiency, family history of thyroid disease, and exposure to radiation. Patients may present with a palpable mass in the neck, but many remain asymptomatic. Diagnosis typically involves a combination of clinical evaluation, thyroid function tests (TFTs), and imaging studies such as ultrasound. TFTs help assess thyroid hormone levels, which can indicate whether the nodule is functioning or not. In cases where malignancy is suspected, fine-needle aspiration biopsy may be performed to obtain tissue samples for histological examination. Management of nontoxic single thyroid nodules may include observation, regular monitoring, or surgical intervention if there are concerns regarding malignancy.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between benign and malignant nodules requires careful evaluation.
  • Documentation must clearly indicate the nodule's characteristics and any associated symptoms.
  • Thyroid function tests must be accurately interpreted and documented.
  • Variability in clinical presentation can complicate coding decisions.

Audit Risk Factors

  • Inadequate documentation of nodule characteristics.
  • Failure to document thyroid function test results.
  • Misclassification of nodule type (benign vs malignant).
  • Lack of follow-up documentation for monitoring nodules.

Specialty Focus

Medical Specialties

Endocrinology

Documentation Requirements

Detailed clinical notes on nodule size, characteristics, and any imaging results.

Common Clinical Scenarios

Patients presenting with a palpable thyroid nodule during routine exams or referrals for abnormal TFTs.

Billing Considerations

Endocrinologists must ensure that all relevant lab results and imaging studies are included in the patient's record.

Surgery

Documentation Requirements

Operative reports detailing the surgical approach and findings during thyroidectomy if performed.

Common Clinical Scenarios

Patients requiring surgical intervention due to suspicion of malignancy or symptomatic nodules.

Billing Considerations

Surgeons should document the rationale for surgery and any preoperative evaluations conducted.

Coding Guidelines

Inclusion Criteria

Use E04.1 When
  • According to ICD
  • 10 guidelines, E04
  • 1 should be used when a single thyroid nodule is confirmed to be nontoxic
  • Documentation must support the diagnosis, including imaging and lab results

Exclusion Criteria

Do NOT use E04.1 When
  • Exclusion criteria include nodules that are toxic or associated with hyperthyroidism

Related ICD-10 Codes

Related CPT Codes

85025CPT Code

Thyroid function tests

Clinical Scenario

Used to assess thyroid hormone levels in patients with thyroid nodules.

Documentation Requirements

Results of TSH, T3, and T4 tests must be documented.

Specialty Considerations

Endocrinologists should ensure that all relevant lab results are included in the patient's record.

60100CPT Code

Fine needle aspiration biopsy of thyroid nodule

Clinical Scenario

Performed when there is suspicion of malignancy in a thyroid nodule.

Documentation Requirements

Biopsy results and indications for the procedure must be documented.

Specialty Considerations

Surgeons should document the rationale for the biopsy and any preoperative evaluations conducted.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of thyroid conditions, improving the accuracy of diagnoses and treatment plans. E04.1 provides a clear distinction between nontoxic and toxic nodules, which is crucial for appropriate management.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of thyroid conditions, improving the accuracy of diagnoses and treatment plans. E04.1 provides a clear distinction between nontoxic and toxic nodules, which is crucial for appropriate management.

Reimbursement & Billing Impact

reimbursement.

Resources

Clinical References

  • •
    American Thyroid Association Guidelines

Coding & Billing References

  • •
    American Thyroid Association Guidelines

Frequently Asked Questions

What is the significance of a nontoxic thyroid nodule?

A nontoxic thyroid nodule is significant as it indicates a localized growth that is not producing excess hormones, but it still requires monitoring to rule out malignancy and assess for any changes in size or symptoms.