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ICD-10 Guide
ICD-10 CodesE06.4

E06.4

Billable

Drug-induced thyroiditis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 E06.4 is a billable code used to indicate a diagnosis of drug-induced thyroiditis.

Key Diagnostic Point:

Drug-induced thyroiditis is a condition characterized by inflammation of the thyroid gland resulting from the administration of certain medications. This condition can lead to alterations in thyroid function, manifesting as either hyperthyroidism or hypothyroidism, depending on the drug involved and the individual’s response. Common medications associated with drug-induced thyroiditis include amiodarone, lithium, and interferons. Clinically, patients may present with symptoms such as fatigue, weight changes, and mood disturbances, which can complicate the diagnosis. Thyroid function tests, including serum TSH, free T4, and free T3 levels, are essential for assessing thyroid function and determining the appropriate management strategy. The condition may resolve upon discontinuation of the offending agent, but in some cases, it may require additional treatment to restore normal thyroid function. Accurate diagnosis and coding are crucial for effective patient management and reimbursement processes.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of medications that can induce thyroiditis
  • Potential overlap with other thyroid disorders
  • Need for comprehensive thyroid function testing
  • Variability in clinical presentation

Audit Risk Factors

  • Inadequate documentation of drug history
  • Failure to specify the type of thyroid dysfunction
  • Lack of thyroid function test results
  • Misidentification of the condition as primary thyroid disease

Specialty Focus

Medical Specialties

Endocrinology

Documentation Requirements

Thorough documentation of medication history, thyroid function tests, and clinical symptoms.

Common Clinical Scenarios

Patients presenting with unexplained thyroid dysfunction after starting new medications.

Billing Considerations

Ensure clear documentation of the timeline between drug initiation and onset of thyroid symptoms.

Primary Care

Documentation Requirements

Complete patient history including medication review and symptom assessment.

Common Clinical Scenarios

Patients with new onset of thyroid symptoms who are on chronic medications.

Billing Considerations

Primary care providers should be vigilant about medication side effects and their potential impact on thyroid health.

Coding Guidelines

Inclusion Criteria

Use E06.4 When
  • According to ICD
  • 10 guidelines, E06
  • 4 should be used when there is clear evidence linking thyroiditis to drug exposure
  • Documentation must support the diagnosis, including medication history and thyroid function test results
  • related etiologies

Exclusion Criteria

Do NOT use E06.4 When
  • Exclusion criteria include thyroiditis due to autoimmune causes or other non

Related ICD-10 Codes

Related CPT Codes

84443CPT Code

Thyroid stimulating hormone (TSH)

Clinical Scenario

Used to assess thyroid function in patients suspected of drug-induced thyroiditis.

Documentation Requirements

Document the reason for testing and any relevant medication history.

Specialty Considerations

Endocrinologists may require additional tests based on initial findings.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of drug-induced conditions, improving the accuracy of diagnoses and treatment tracking. E06.4 provides a clear distinction from other thyroid disorders, facilitating better patient management and research.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of drug-induced conditions, improving the accuracy of diagnoses and treatment tracking. E06.4 provides a clear distinction from other thyroid disorders, facilitating better patient management and research.

Reimbursement & Billing Impact

reimbursement.

Resources

Clinical References

  • •
    American Thyroid Association Guidelines

Coding & Billing References

  • •
    American Thyroid Association Guidelines

Frequently Asked Questions

What medications are commonly associated with drug-induced thyroiditis?

Common medications include amiodarone, lithium, and interferons. Each of these can affect thyroid function differently, leading to either hyperthyroidism or hypothyroidism.