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ICD-10 Guide
ICD-10 CodesE22.9

E22.9

Billable

Hyperfunction of pituitary gland, unspecified

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 E22.9 is a billable code used to indicate a diagnosis of hyperfunction of pituitary gland, unspecified.

Key Diagnostic Point:

Hyperfunction of the pituitary gland refers to an overproduction of hormones due to excessive activity of the pituitary gland. This condition can lead to various endocrine disorders, as the pituitary gland plays a crucial role in regulating hormone levels throughout the body. The hyperfunction may result in conditions such as acromegaly, Cushing's disease, or hyperprolactinemia, depending on which hormones are overproduced. Symptoms can vary widely, including abnormal growth patterns, metabolic disturbances, and reproductive issues. Diagnosis typically involves hormonal assays, imaging studies like MRI, and clinical evaluation. Treatment may include medication, surgery, or radiation therapy, depending on the underlying cause and severity of the hyperfunction. The unspecified nature of this code indicates that the specific hormone or disorder has not been identified, which can complicate treatment and management strategies.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in symptoms and clinical presentation
  • Need for comprehensive hormonal evaluation
  • Potential overlap with other endocrine disorders
  • Diagnostic imaging requirements

Audit Risk Factors

  • Insufficient documentation of symptoms
  • Lack of clear diagnostic criteria
  • Inadequate follow-up notes on treatment response
  • Failure to document imaging studies

Specialty Focus

Medical Specialties

Endocrinology

Documentation Requirements

Detailed hormonal assay results, imaging studies, and clinical evaluations must be documented.

Common Clinical Scenarios

Patients presenting with symptoms of hormone excess, such as abnormal growth or metabolic changes.

Billing Considerations

Endocrinologists should ensure that all relevant lab results and imaging studies are included in the patient's record to support the diagnosis.

Internal Medicine

Documentation Requirements

Comprehensive patient history and physical examination findings related to endocrine function.

Common Clinical Scenarios

Patients with unexplained weight changes, fatigue, or reproductive issues.

Billing Considerations

Internal medicine practitioners should be aware of the potential for overlapping symptoms with other conditions.

Coding Guidelines

Inclusion Criteria

Use E22.9 When
  • Follow the official ICD
  • CM coding guidelines, ensuring that the diagnosis is supported by clinical documentation
  • This code is used when the hyperfunction is unspecified, and further specificity is not available

Exclusion Criteria

Do NOT use E22.9 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

83001CPT Code

Growth hormone (GH) test

Clinical Scenario

Used to evaluate suspected growth hormone excess.

Documentation Requirements

Document the reason for testing and any relevant clinical findings.

Specialty Considerations

Endocrinologists should ensure that the test results are interpreted in the context of the patient's overall clinical picture.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of endocrine disorders, but the unspecified nature of E22.9 can lead to challenges in accurately capturing the complexity of patient conditions.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of endocrine disorders, but the unspecified nature of E22.9 can lead to challenges in accurately capturing the complexity of patient conditions.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of endocrine disorders, but the unspecified nature of E22.9 can lead to challenges in accurately capturing the complexity of patient conditions.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What should I document to support the use of E22.9?

Document all relevant clinical findings, lab results, imaging studies, and any symptoms that indicate hyperfunction of the pituitary gland. Ensure that the rationale for the diagnosis is clear.