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v1.0.0
ICD-10 Guide
ICD-10 CodesE27.1

E27.1

Billable

Primary adrenocortical insufficiency

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 E27.1 is a billable code used to indicate a diagnosis of primary adrenocortical insufficiency.

Key Diagnostic Point:

Primary adrenocortical insufficiency, also known as Addison's disease, is a disorder characterized by the inadequate production of adrenal hormones, particularly cortisol and aldosterone, due to damage to the adrenal cortex. This condition can arise from autoimmune destruction of the adrenal glands, infections, or other factors leading to adrenal gland dysfunction. Patients may present with symptoms such as fatigue, weight loss, low blood pressure, hyperpigmentation of the skin, and electrolyte imbalances. The condition can also lead to secondary effects on other endocrine glands, including the pituitary gland, which may increase adrenocorticotropic hormone (ACTH) levels in response to low cortisol. Diagnosis typically involves hormonal assays, imaging studies, and sometimes stimulation tests to assess adrenal function. Management includes hormone replacement therapy to restore normal hormone levels and address symptoms. Regular monitoring is essential to adjust treatment and prevent adrenal crises, which can be life-threatening.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between primary and secondary adrenal insufficiency
  • Understanding the interplay between adrenal, pituitary, and parathyroid hormones
  • Variability in clinical presentation among patients
  • Need for comprehensive documentation of symptoms and lab results

Audit Risk Factors

  • Inadequate documentation of hormone levels
  • Failure to document the cause of adrenal insufficiency
  • Misclassification of primary vs. secondary adrenal insufficiency
  • Lack of follow-up documentation for treatment response

Specialty Focus

Medical Specialties

Endocrinology

Documentation Requirements

Detailed hormone level assessments, imaging studies, and patient history.

Common Clinical Scenarios

Patients presenting with fatigue, weight loss, and hypotension; patients with known autoimmune disorders.

Billing Considerations

Ensure documentation reflects the cause of adrenal insufficiency and any associated conditions.

Internal Medicine

Documentation Requirements

Comprehensive patient history, physical examination findings, and lab results.

Common Clinical Scenarios

Patients with unexplained fatigue or hypotension; patients with electrolyte imbalances.

Billing Considerations

Documenting the clinical rationale for testing and treatment adjustments is crucial.

Coding Guidelines

Inclusion Criteria

Use E27.1 When
  • Follow the official ICD
  • CM coding guidelines, ensuring accurate documentation of the diagnosis, including the cause of adrenal insufficiency
  • Include any relevant lab results and treatment plans

Exclusion Criteria

Do NOT use E27.1 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

84436CPT Code

Cortisol, serum

Clinical Scenario

Used to confirm diagnosis of adrenal insufficiency.

Documentation Requirements

Document the reason for testing and results.

Specialty Considerations

Endocrinologists should ensure comprehensive lab panels are ordered.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of adrenal disorders, improving the accuracy of diagnoses and treatment tracking for primary adrenocortical insufficiency.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of adrenal disorders, improving the accuracy of diagnoses and treatment tracking for primary adrenocortical insufficiency.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of adrenal disorders, improving the accuracy of diagnoses and treatment tracking for primary adrenocortical insufficiency.

Resources

Clinical References

  • •
    Addison's Disease Foundation

Coding & Billing References

  • •
    Addison's Disease Foundation

Frequently Asked Questions

What are the common symptoms of primary adrenocortical insufficiency?

Common symptoms include fatigue, weight loss, low blood pressure, hyperpigmentation, and electrolyte imbalances.

How is primary adrenocortical insufficiency diagnosed?

Diagnosis typically involves hormonal assays, imaging studies, and sometimes stimulation tests to assess adrenal function.

What is the treatment for primary adrenocortical insufficiency?

Treatment involves lifelong hormone replacement therapy to restore normal hormone levels and manage symptoms.