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ICD-10 Guide
ICD-10 CodesE28.319

E28.319

Billable

Asymptomatic premature menopause

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 E28.319 is a billable code used to indicate a diagnosis of asymptomatic premature menopause.

Key Diagnostic Point:

Asymptomatic premature menopause refers to the cessation of menstrual periods before the age of 40 without the presence of typical menopausal symptoms such as hot flashes, night sweats, or mood changes. This condition can arise from various factors, including genetic predispositions, autoimmune disorders, or surgical interventions affecting the ovaries. The diagnosis is often made through clinical evaluation and hormone level testing, particularly measuring follicle-stimulating hormone (FSH) and estradiol levels. Elevated FSH levels alongside low estradiol levels can indicate ovarian insufficiency. While the patient may not exhibit symptoms, the implications of premature menopause can include long-term health risks such as osteoporosis and cardiovascular disease due to decreased estrogen levels. It is essential for healthcare providers to monitor these patients closely and consider preventive measures to mitigate these risks.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between symptomatic and asymptomatic cases
  • Understanding the underlying causes of premature menopause
  • Interpreting hormone level tests accurately
  • Co-existing endocrine disorders that may complicate diagnosis

Audit Risk Factors

  • Inadequate documentation of hormone levels
  • Failure to note the absence of symptoms
  • Misclassification of premature menopause as primary ovarian insufficiency
  • Lack of follow-up care documentation

Specialty Focus

Medical Specialties

Endocrinology

Documentation Requirements

Detailed hormone level tests, patient history, and any relevant imaging studies.

Common Clinical Scenarios

Patients presenting with irregular menstrual cycles, family history of early menopause, or unexplained infertility.

Billing Considerations

Endocrinologists must ensure comprehensive evaluations to rule out other endocrine disorders that may mimic or contribute to premature menopause.

Gynecology

Documentation Requirements

Menstrual history, symptom assessment, and any surgical history related to reproductive health.

Common Clinical Scenarios

Women under 40 presenting with missed periods or fertility concerns.

Billing Considerations

Gynecologists should document any psychosocial impacts of premature menopause on the patient.

Coding Guidelines

Inclusion Criteria

Use E28.319 When
  • According to ICD
  • 10 guidelines, E28
  • 319 should be used when a patient is diagnosed with premature menopause without symptoms
  • Documentation must support the diagnosis, including hormone levels and absence of menopausal symptoms

Exclusion Criteria

Do NOT use E28.319 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

83001CPT Code

FSH test

Clinical Scenario

Used to confirm diagnosis of premature menopause.

Documentation Requirements

Document the reason for the test and results.

Specialty Considerations

Endocrinologists should ensure comprehensive hormone panels are included.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of conditions like asymptomatic premature menopause, improving the accuracy of diagnoses and treatment plans.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of conditions like asymptomatic premature menopause, improving the accuracy of diagnoses and treatment plans.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of conditions like asymptomatic premature menopause, improving the accuracy of diagnoses and treatment plans.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What is the difference between E28.319 and E28.310?

E28.319 is used for asymptomatic premature menopause, while E28.310 is for cases where the patient exhibits symptoms such as hot flashes or mood changes.