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ICD-10 Guide
ICD-10 CodesF11.21

F11.21

Billable

Opioid dependence, in remission

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 F11.21 is a billable code used to indicate a diagnosis of opioid dependence, in remission.

Key Diagnostic Point:

Opioid dependence, in remission, refers to a state where an individual has previously met the criteria for opioid dependence but is currently not experiencing any symptoms of the disorder. This condition is characterized by a significant reduction or complete cessation of opioid use, and the individual may have engaged in treatment programs aimed at recovery. The remission can be classified as either partial or full, depending on the presence of any residual symptoms or cravings. Treatment often involves a combination of behavioral therapies, counseling, and possibly medication-assisted treatment (MAT) such as buprenorphine or methadone. It is essential to monitor the individual for any signs of relapse, as the risk remains elevated even in remission. The diagnosis requires careful assessment and documentation of the individual's history of opioid use, treatment interventions, and current status regarding opioid use and dependence symptoms.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between remission and active dependence
  • Need for comprehensive patient history documentation
  • Potential for co-occurring substance use disorders
  • Variability in treatment approaches and outcomes

Audit Risk Factors

  • Inadequate documentation of remission status
  • Failure to document treatment history
  • Misclassification of active dependence vs. remission
  • Lack of follow-up assessments

Specialty Focus

Medical Specialties

Addiction Medicine

Documentation Requirements

Detailed treatment history, current status, and any ongoing therapies.

Common Clinical Scenarios

Patients transitioning from active opioid use to remission, those in MAT programs.

Billing Considerations

Ensure clear documentation of remission status and any ongoing support or therapy.

Psychiatry

Documentation Requirements

Mental health evaluations, history of substance use, and treatment plans.

Common Clinical Scenarios

Patients with co-occurring mental health disorders and opioid dependence.

Billing Considerations

Document any psychological assessments and their relation to opioid use.

Coding Guidelines

Inclusion Criteria

Use F11.21 When
  • According to ICD
  • 10 guidelines, F11
  • 21 should be used when the patient has a documented history of opioid dependence but is currently not exhibiting symptoms
  • Documentation must include the duration of remission and any treatment interventions

Exclusion Criteria

Do NOT use F11.21 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

H0033CPT Code

Medication-assisted treatment

Clinical Scenario

Used when a patient is receiving MAT for opioid dependence.

Documentation Requirements

Document the type of medication, dosage, and treatment plan.

Specialty Considerations

Addiction specialists should ensure comprehensive treatment records.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of opioid-related disorders, including the distinction between active dependence and remission, which aids in better tracking and treatment planning.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of opioid-related disorders, including the distinction between active dependence and remission, which aids in better tracking and treatment planning.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of opioid-related disorders, including the distinction between active dependence and remission, which aids in better tracking and treatment planning.

Resources

Clinical References

  • •
    Substance Abuse and Mental Health Services Administration (SAMHSA)

Coding & Billing References

  • •
    Substance Abuse and Mental Health Services Administration (SAMHSA)

Frequently Asked Questions

What does 'in remission' mean in the context of opioid dependence?

In remission means that the individual has previously met the criteria for opioid dependence but is currently not experiencing any symptoms or cravings associated with the disorder.