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ICD-10 Guide
ICD-10 CodesG04.01

G04.01

Billable

Postinfectious acute disseminated encephalitis and encephalomyelitis (postinfectious ADEM)

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 G04.01 is a billable code used to indicate a diagnosis of postinfectious acute disseminated encephalitis and encephalomyelitis (postinfectious adem).

Key Diagnostic Point:

Postinfectious acute disseminated encephalitis and encephalomyelitis (postinfectious ADEM) is a neurological condition characterized by widespread inflammation of the brain and spinal cord that occurs following an infection. This condition is often triggered by viral infections, such as those caused by the measles, mumps, rubella, or varicella viruses, and can also follow bacterial infections. Clinically, patients may present with a range of symptoms including fever, headache, altered mental status, seizures, and focal neurological deficits. The pathophysiology involves an autoimmune response where the immune system mistakenly attacks the central nervous system (CNS) tissues after the initial infection has resolved. Diagnosis typically involves neuroimaging, such as MRI, which may show lesions in the brain, and lumbar puncture to analyze cerebrospinal fluid (CSF) for inflammatory markers. Treatment often includes corticosteroids to reduce inflammation and supportive care. Early recognition and management are crucial to improve outcomes and minimize long-term neurological deficits.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating from other types of encephalitis and encephalomyelitis
  • Need for comprehensive documentation of prior infections
  • Variability in clinical presentation among patients
  • Potential overlap with other neurological conditions

Audit Risk Factors

  • Insufficient documentation linking infection to neurological symptoms
  • Lack of detailed clinical notes on the patient's history
  • Inadequate neuroimaging or CSF analysis documentation
  • Misclassification of the type of encephalitis

Specialty Focus

Medical Specialties

Neurology

Documentation Requirements

Detailed clinical notes on neurological examination, history of infections, and diagnostic imaging results.

Common Clinical Scenarios

Patients presenting with acute neurological symptoms following a viral illness.

Billing Considerations

Ensure that all relevant lab results and imaging studies are included in the documentation.

Infectious Disease

Documentation Requirements

Thorough history of infectious diseases, laboratory results, and treatment plans.

Common Clinical Scenarios

Patients with a history of recent infections presenting with neurological symptoms.

Billing Considerations

Document the timeline of infection and neurological symptom onset clearly.

Coding Guidelines

Inclusion Criteria

Use G04.01 When
  • According to ICD
  • 10 guidelines, G04
  • 01 should be used when the condition is specifically postinfectious and there is clear documentation of the preceding infection
  • It is important to differentiate it from other encephalitis codes that do not specify a postinfectious etiology

Exclusion Criteria

Do NOT use G04.01 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

70450CPT Code

CT scan of the head

Clinical Scenario

Used to evaluate for signs of encephalitis in patients presenting with neurological symptoms.

Documentation Requirements

Document the clinical indications for the CT scan and findings.

Specialty Considerations

Neurologists should ensure that the rationale for imaging is clearly stated.

62270CPT Code

Lumbar puncture

Clinical Scenario

Performed to analyze CSF in suspected cases of ADEM.

Documentation Requirements

Document the indication for the procedure and results of CSF analysis.

Specialty Considerations

Infectious disease specialists should document the timeline of infection and neurological symptoms.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of postinfectious conditions like ADEM, improving the accuracy of diagnoses and treatment tracking. This specificity helps in better understanding the epidemiology and outcomes of such conditions.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of postinfectious conditions like ADEM, improving the accuracy of diagnoses and treatment tracking. This specificity helps in better understanding the epidemiology and outcomes of such conditions.

Reimbursement & Billing Impact

reimbursement.

Resources

Clinical References

  • •
    CDC - Encephalitis
  • •
    National Institute of Neurological Disorders and Stroke - ADEM

Coding & Billing References

  • •
    CDC - Encephalitis
  • •
    National Institute of Neurological Disorders and Stroke - ADEM

Frequently Asked Questions

What is the primary cause of postinfectious ADEM?

Postinfectious ADEM is primarily caused by an autoimmune response following viral infections, where the immune system attacks the CNS after the infection has resolved.

How is postinfectious ADEM diagnosed?

Diagnosis is made based on clinical symptoms, neuroimaging findings, and analysis of cerebrospinal fluid, which may show elevated white blood cells and protein levels.