ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesG12.23

G12.23

Billable

Primary lateral sclerosis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 G12.23 is a billable code used to indicate a diagnosis of primary lateral sclerosis.

Key Diagnostic Point:

Primary lateral sclerosis (PLS) is a rare neurodegenerative disorder characterized by the progressive degeneration of upper motor neurons in the brain and spinal cord. This condition leads to muscle weakness, stiffness, and spasticity, primarily affecting voluntary movements. Patients may experience difficulty with walking, fine motor skills, and speech, as the disease progresses. Unlike amyotrophic lateral sclerosis (ALS), PLS does not typically involve lower motor neuron degeneration, which means that patients may retain some muscle strength and function for a longer period. The onset of PLS is usually gradual, with symptoms often beginning in the legs and then spreading to other parts of the body. Diagnosis is primarily clinical, based on the history of symptoms and neurological examination, often requiring exclusion of other motor neuron diseases and conditions such as multiple sclerosis or hereditary spastic paraplegia. Genetic factors may play a role in some cases, but PLS is generally considered sporadic rather than hereditary. Management focuses on symptomatic relief and supportive care, including physical therapy and medications to manage spasticity.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiation from other motor neuron diseases like ALS.
  • Need for comprehensive neurological evaluation.
  • Potential overlap with hereditary spastic paraplegia.
  • Documentation of symptom progression and functional impairment.

Audit Risk Factors

  • Inadequate documentation of symptom onset and progression.
  • Failure to exclude other similar diagnoses.
  • Lack of detailed neurological examination notes.
  • Misclassification of PLS as ALS or other motor neuron diseases.

Specialty Focus

Medical Specialties

Neurology

Documentation Requirements

Detailed neurological examination findings, history of symptoms, and progression notes.

Common Clinical Scenarios

Patients presenting with spasticity, weakness, and gait disturbances.

Billing Considerations

Ensure clear documentation of upper motor neuron signs and exclusion of lower motor neuron involvement.

Physical Medicine and Rehabilitation

Documentation Requirements

Functional assessments, treatment plans, and progress notes.

Common Clinical Scenarios

Rehabilitation needs for patients with mobility issues due to PLS.

Billing Considerations

Focus on documenting the impact of PLS on daily activities and rehabilitation goals.

Coding Guidelines

Inclusion Criteria

Use G12.23 When
  • Follow official ICD
  • PLS should be coded only when a definitive diagnosis is made, supported by clinical findings

Exclusion Criteria

Do NOT use G12.23 When
  • 10 coding guidelines, ensuring accurate documentation of symptoms, progression, and exclusion of other conditions

Related ICD-10 Codes

Related CPT Codes

99214CPT Code

Established patient office visit, level 4

Clinical Scenario

Used for follow-up visits for patients with PLS to assess progression and management.

Documentation Requirements

Detailed history, examination findings, and treatment plan.

Specialty Considerations

Neurology specialists should document neurological assessments thoroughly.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of conditions like PLS, improving the accuracy of data collection and reimbursement processes. It has also facilitated better tracking of rare diseases and their management.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of conditions like PLS, improving the accuracy of data collection and reimbursement processes. It has also facilitated better tracking of rare diseases and their management.

Reimbursement & Billing Impact

reimbursement processes. It has also facilitated better tracking of rare diseases and their management.

Resources

Clinical References

  • •
    National Institute of Neurological Disorders and Stroke

Coding & Billing References

  • •
    National Institute of Neurological Disorders and Stroke

Frequently Asked Questions

What are the main symptoms of primary lateral sclerosis?

The main symptoms include muscle weakness, spasticity, difficulty with coordination, and changes in speech. Symptoms typically begin in the legs and may progress to other areas of the body.