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ICD-10 Guide
ICD-10 CodesG21.1

G21.1

Billable

Other drug-induced secondary parkinsonism

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 G21.1 is a billable code used to indicate a diagnosis of other drug-induced secondary parkinsonism.

Key Diagnostic Point:

Other drug-induced secondary parkinsonism refers to a form of parkinsonism that arises as a consequence of exposure to certain medications, particularly those that affect dopaminergic pathways in the brain. This condition is characterized by symptoms similar to Parkinson's disease, including bradykinesia, rigidity, and tremors, but is distinct in that it is directly linked to pharmacological agents. Common culprits include antipsychotics, antiemetics, and certain antidepressants, which can induce extrapyramidal symptoms due to their dopamine-blocking effects. The onset of symptoms may occur shortly after starting the offending medication or increasing the dosage. Diagnosis typically involves a thorough medication history and clinical evaluation to rule out primary Parkinson's disease and other movement disorders. Management often includes discontinuation or adjustment of the offending drug, and in some cases, the use of anticholinergic medications or beta-blockers may be considered to alleviate symptoms. Understanding the relationship between drug exposure and parkinsonism is crucial for effective treatment and patient safety.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between primary and secondary parkinsonism
  • Identifying the specific drug responsible for symptoms
  • Understanding the timeline of symptom onset relative to medication use
  • Documenting the patient's complete medication history

Audit Risk Factors

  • Inadequate documentation of medication history
  • Failure to specify the drug causing symptoms
  • Misclassification of primary vs. secondary parkinsonism
  • Lack of clinical correlation between symptoms and medication use

Specialty Focus

Medical Specialties

Neurology

Documentation Requirements

Detailed patient history, including medication use, symptom onset, and neurological examination findings.

Common Clinical Scenarios

Patients presenting with new-onset parkinsonism after starting antipsychotic medications.

Billing Considerations

Neurologists must ensure that all potential causes of parkinsonism are considered and documented.

Psychiatry

Documentation Requirements

Documentation of psychiatric medications prescribed, including dosages and duration of treatment.

Common Clinical Scenarios

Patients experiencing extrapyramidal symptoms after initiation of antipsychotic therapy.

Billing Considerations

Psychiatrists should monitor for movement disorders in patients on long-term antipsychotic therapy.

Coding Guidelines

Inclusion Criteria

Use G21.1 When
  • According to ICD
  • 10 coding guidelines, G21
  • 1 should be used when parkinsonism is clearly linked to a specific drug
  • Coders must ensure that the documentation supports the diagnosis and that the drug responsible is identified

Exclusion Criteria

Do NOT use G21.1 When
  • Exclusion criteria include primary parkinsonism and other movement disorders not induced by medication

Related ICD-10 Codes

Related CPT Codes

99213CPT Code

Established patient office visit, Level 3

Clinical Scenario

Used for follow-up visits of patients with drug-induced parkinsonism.

Documentation Requirements

Document the patient's medication history and current symptoms.

Specialty Considerations

Neurologists and psychiatrists should ensure comprehensive evaluations are documented.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of drug-induced parkinsonism, improving the ability to track and manage these cases effectively. It has also emphasized the importance of detailed documentation regarding medication histories.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of drug-induced parkinsonism, improving the ability to track and manage these cases effectively. It has also emphasized the importance of detailed documentation regarding medication histories.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of drug-induced parkinsonism, improving the ability to track and manage these cases effectively. It has also emphasized the importance of detailed documentation regarding medication histories.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What medications are commonly associated with G21.1?

Common medications include antipsychotics (e.g., haloperidol, risperidone), antiemetics (e.g., metoclopramide), and certain antidepressants that have dopaminergic effects.