Immune effector cell-associated neurotoxicity syndrome, grade 1
ICD-10 G92.01 is a billable code used to indicate a diagnosis of immune effector cell-associated neurotoxicity syndrome, grade 1.
Immune effector cell-associated neurotoxicity syndrome (ICANS) is a neurological complication that can occur following immunotherapy, particularly with CAR T-cell therapy. Grade 1 ICANS is characterized by mild symptoms that may include headache, fatigue, and mild confusion, which do not significantly impair daily functioning. Patients may experience transient neurological symptoms, such as mild motor weakness or sensory changes, but these symptoms are typically self-limiting and resolve without the need for intensive intervention. The pathophysiology of ICANS involves the activation of immune effector cells that can lead to neuroinflammation and disruption of the blood-brain barrier. Clinicians must monitor patients closely for any progression of symptoms, as the syndrome can escalate to higher grades of severity, necessitating more aggressive management. Early recognition and appropriate coding of ICANS are crucial for ensuring proper treatment and reimbursement.
Detailed records of immunotherapy treatment, patient symptoms, and neurological assessments.
Patients receiving CAR T-cell therapy presenting with neurological symptoms.
Close monitoring for symptom progression and timely documentation of any changes in neurological status.
Comprehensive neurological evaluations and assessments of cognitive function.
Patients with ICANS presenting with confusion or mild motor deficits.
Differentiating ICANS from other neurological disorders such as encephalitis or stroke.
Used when administering CAR T-cell therapy, which may lead to ICANS.
Document the administration details and any observed neurological symptoms.
Oncology specialists should ensure thorough documentation of patient responses post-therapy.
Grade 1 ICANS symptoms may include mild confusion, headache, fatigue, and transient sensory changes that do not significantly impair daily functioning.
