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ICD-10 Guide
ICD-10 CodesI21.4

I21.4

Billable

Non-ST elevation (NSTEMI) myocardial infarction

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/06/2025

Code Description

ICD-10 I21.4 is a billable code used to indicate a diagnosis of non-st elevation (nstemi) myocardial infarction.

Key Diagnostic Point:

Non-ST elevation myocardial infarction (NSTEMI) is a type of heart attack characterized by the absence of ST-segment elevation on an electrocardiogram (ECG). It occurs when there is a partial blockage of blood flow to the heart muscle, typically due to a ruptured atherosclerotic plaque and subsequent thrombosis. Clinically, patients may present with chest pain, shortness of breath, and other symptoms of ischemia. The anatomy involved includes the coronary arteries supplying blood to the myocardium, particularly the left anterior descending artery, right coronary artery, and circumflex artery. Disease progression can lead to significant myocardial damage if not promptly treated, and it may result in complications such as heart failure or arrhythmias. Diagnostic considerations include ECG findings, cardiac biomarkers (e.g., troponin levels), and imaging studies. Timely diagnosis and management are crucial to improving outcomes and preventing further cardiovascular events.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Diagnostic complexity: Requires interpretation of ECG and biomarker levels.
  • Treatment complexity: Involves medication management, potential catheterization, and lifestyle modifications.
  • Documentation requirements: Detailed clinical notes and evidence of diagnostic criteria are necessary.
  • Coding specificity: Requires accurate coding to differentiate from ST elevation myocardial infarction (STEMI) and unstable angina.

Audit Risk Factors

  • Common coding errors: Misclassification between NSTEMI and unstable angina.
  • Documentation gaps: Incomplete clinical notes regarding symptoms and diagnostic tests.
  • Billing challenges: Potential denials due to insufficient documentation supporting the diagnosis.

Specialty Focus

Medical Specialties

Cardiology

Documentation Requirements

Standard ICD-10-CM documentation requirements apply

Common Clinical Scenarios

Various clinical presentations within this specialty area

Billing Considerations

Follow specialty-specific billing guidelines

Emergency Medicine

Documentation Requirements

Standard ICD-10-CM documentation requirements apply

Common Clinical Scenarios

Various clinical presentations within this specialty area

Billing Considerations

Follow specialty-specific billing guidelines

Related ICD-10 Codes

Related CPT Codes

CPT Code

Clinical Scenario

Documentation Requirements

CPT Code

Clinical Scenario

Documentation Requirements

CPT Code

Clinical Scenario

Documentation Requirements

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

NSTEMI has significant clinical implications, as it represents a critical point in the continuum of coronary artery disease. The population health impact is substantial, with millions affected globally, leading to increased healthcare utilization and costs. Quality measures focus on timely diagnosis and treatment to reduce morbidity and mortality associated with myocardial infarctions. Epidemiologically, NSTEMI is a leading cause of hospitalization and can lead to long-term health complications, emphasizing the need for effective management strategies.

ICD-9 vs ICD-10

NSTEMI has significant clinical implications, as it represents a critical point in the continuum of coronary artery disease. The population health impact is substantial, with millions affected globally, leading to increased healthcare utilization and costs. Quality measures focus on timely diagnosis and treatment to reduce morbidity and mortality associated with myocardial infarctions. Epidemiologically, NSTEMI is a leading cause of hospitalization and can lead to long-term health complications, emphasizing the need for effective management strategies.

Reimbursement & Billing Impact

Reimbursement considerations include the use of appropriate CPT codes for diagnostic tests such as ECGs and cardiac enzyme assays. Common denials may arise from insufficient documentation or failure to meet medical necessity criteria. Best practices include ensuring that all clinical findings are well-documented and that the coding accurately reflects the patient's condition and treatment provided.

Resources

Clinical References

  • •
    ICD-10 Official Guidelines for I00-I99
  • •
    Clinical Documentation Requirements

Coding & Billing References

  • •
    ICD-10 Official Guidelines for I00-I99
  • •
    Clinical Documentation Requirements

Frequently Asked Questions

What specific conditions are covered by I21.4?

I21.4 covers non-ST elevation myocardial infarction, which is diagnosed based on clinical symptoms, elevated cardiac biomarkers, and ECG findings that do not show ST-segment elevation.

When should I21.4 be used instead of related codes?

I21.4 should be used when a patient presents with symptoms of myocardial infarction, has elevated cardiac markers, but does not exhibit ST-segment elevation on the ECG, differentiating it from STEMI and unstable angina.

What documentation supports I21.4?

Documentation should include a detailed account of the patient's symptoms, results of ECG and cardiac biomarker tests, and any imaging studies performed to support the diagnosis of NSTEMI.