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ICD-10 Guide
ICD-10 CodesI33.0

I33.0

Billable

Acute and subacute infective endocarditis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/06/2025

Code Description

ICD-10 I33.0 is a billable code used to indicate a diagnosis of acute and subacute infective endocarditis.

Key Diagnostic Point:

Acute and subacute infective endocarditis (IE) is an infection of the inner lining of the heart chambers and valves, primarily caused by bacteria, fungi, or other infectious agents. Clinically, patients may present with symptoms such as fever, chills, fatigue, and heart murmurs, alongside signs of systemic embolization. The anatomy involved includes the heart valves (mitral, aortic, tricuspid, and pulmonary) and the endocardium. Disease progression can vary; acute infective endocarditis develops rapidly, often leading to severe complications within days to weeks, while subacute infective endocarditis progresses more slowly, potentially allowing for a more insidious onset of symptoms. Diagnostic considerations include blood cultures, echocardiography (transthoracic or transesophageal), and laboratory tests to identify the causative organism and assess for complications such as heart failure or abscess formation. Early diagnosis and treatment are crucial to prevent severe morbidity and mortality associated with this condition.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Diagnostic complexity: Requires thorough clinical evaluation and multiple diagnostic tests.
  • Treatment complexity: Involves prolonged antibiotic therapy, potential surgical intervention, and management of complications.
  • Documentation requirements: Detailed clinical documentation is necessary to support the diagnosis and treatment plan.
  • Coding specificity: Requires precise coding to differentiate between acute and subacute forms, as well as the causative organism.

Audit Risk Factors

  • Common coding errors: Misclassification between acute and subacute forms.
  • Documentation gaps: Insufficient detail in clinical notes regarding symptoms, diagnostic tests, and treatment plans.
  • Billing challenges: Potential for denials if documentation does not clearly support the diagnosis and treatment provided.

Specialty Focus

Medical Specialties

Cardiology

Documentation Requirements

Standard ICD-10-CM documentation requirements apply

Common Clinical Scenarios

Various clinical presentations within this specialty area

Billing Considerations

Follow specialty-specific billing guidelines

Infectious Disease

Documentation Requirements

Standard ICD-10-CM documentation requirements apply

Common Clinical Scenarios

Various clinical presentations within this specialty area

Billing Considerations

Follow specialty-specific billing guidelines

Related ICD-10 Codes

Related CPT Codes

CPT Code

Clinical Scenario

Documentation Requirements

CPT Code

Clinical Scenario

Documentation Requirements

CPT Code

Clinical Scenario

Documentation Requirements

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

Infective endocarditis has significant clinical implications, as it can lead to severe complications such as heart failure, stroke, and death if not promptly diagnosed and treated. The condition has a notable impact on population health, particularly among individuals with pre-existing heart conditions or those at risk due to intravenous drug use. Quality measures related to timely diagnosis and appropriate antibiotic therapy are critical for improving outcomes and reducing healthcare utilization associated with this serious cardiovascular condition.

ICD-9 vs ICD-10

Infective endocarditis has significant clinical implications, as it can lead to severe complications such as heart failure, stroke, and death if not promptly diagnosed and treated. The condition has a notable impact on population health, particularly among individuals with pre-existing heart conditions or those at risk due to intravenous drug use. Quality measures related to timely diagnosis and appropriate antibiotic therapy are critical for improving outcomes and reducing healthcare utilization associated with this serious cardiovascular condition.

Reimbursement & Billing Impact

Reimbursement considerations may vary based on the severity of the condition and the complexity of treatment provided. Common denials may arise from insufficient documentation or failure to meet medical necessity criteria. Best practices include ensuring that all clinical notes are detailed and that coding accurately reflects the diagnosis and treatment provided to minimize audit risks.

Resources

Clinical References

  • •
    ICD-10 Official Guidelines for I00-I99
  • •
    Clinical Documentation Requirements

Coding & Billing References

  • •
    ICD-10 Official Guidelines for I00-I99
  • •
    Clinical Documentation Requirements

Frequently Asked Questions

What specific conditions are covered by I33.0?

I33.0 specifically covers acute and subacute infective endocarditis, which may be caused by various pathogens including Streptococcus, Staphylococcus, and enterococci. It is characterized by the rapid onset of symptoms in acute cases and a more gradual presentation in subacute cases.

When should I33.0 be used instead of related codes?

I33.0 should be used when the patient is diagnosed with acute or subacute infective endocarditis, as opposed to other forms of endocarditis or heart infections. Accurate differentiation is essential for appropriate treatment and coding.

What documentation supports I33.0?

Documentation should include clinical findings such as fever, heart murmurs, and embolic phenomena, results from blood cultures, echocardiography findings, and treatment plans. Comprehensive notes detailing the patient's history and clinical course are also essential.