Myositis ossificans progressiva
ICD-10 M61.1 is a billable code used to indicate a diagnosis of myositis ossificans progressiva.
Myositis ossificans progressiva (MOP) is a rare genetic disorder characterized by the abnormal formation of bone in muscles, tendons, and other connective tissues. This condition is caused by mutations in the ACVR1 gene, which plays a crucial role in the regulation of bone growth and development. Patients with MOP typically experience progressive muscle stiffness and weakness, often beginning in childhood or early adulthood. The hallmark of this disorder is the formation of heterotopic ossification, where bone tissue forms in areas where it should not, leading to significant mobility limitations and pain. The condition is often misdiagnosed as other muscle disorders due to its symptoms, which can include muscle swelling, tenderness, and decreased range of motion. Diagnosis is primarily clinical, supported by imaging studies that reveal abnormal bone formation. Management is symptomatic, focusing on pain relief and maintaining mobility, as surgical intervention can exacerbate the condition. Understanding the genetic basis and clinical presentation of MOP is essential for accurate diagnosis and management.
Detailed family history and genetic testing results must be documented.
Patients presenting with unexplained muscle stiffness and pain, particularly in childhood.
Genetic counseling may be necessary for affected families.
Comprehensive assessment of mobility limitations and imaging studies showing ossification.
Patients requiring surgical evaluation for mobility issues due to heterotopic ossification.
Surgical interventions should be approached with caution due to the risk of exacerbating the condition.
Used when a patient is suspected of having MOP based on clinical symptoms.
Documentation of clinical symptoms and family history is required to justify genetic testing.
Genetic specialists should ensure comprehensive family history is included.
Common symptoms include progressive muscle stiffness, weakness, swelling, and pain in affected areas, often leading to significant mobility limitations.
