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ICD-10 Guide
ICD-10 CodesN05.3

N05.3

Billable

Unspecified nephritic syndrome with diffuse mesangial proliferative glomerulonephritis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/18/2025

Code Description

ICD-10 N05.3 is a billable code used to indicate a diagnosis of unspecified nephritic syndrome with diffuse mesangial proliferative glomerulonephritis.

Key Diagnostic Point:

Unspecified nephritic syndrome with diffuse mesangial proliferative glomerulonephritis is characterized by the presence of nephritic syndrome symptoms, including hematuria, proteinuria, and hypertension, alongside histological findings of diffuse mesangial proliferation in the glomeruli. This condition often presents with a combination of renal impairment and systemic symptoms, such as edema and fatigue. The diffuse mesangial proliferation indicates an increase in mesangial cell number, which can lead to glomerular dysfunction. Diagnosis typically involves renal biopsy, which reveals the characteristic histological changes. Management may include corticosteroids and immunosuppressive agents, depending on the underlying cause and severity of the disease. Regular monitoring of renal function and proteinuria is essential to assess treatment efficacy and disease progression.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in clinical presentation and underlying causes
  • Need for precise documentation of symptoms and biopsy findings
  • Differentiation from other types of glomerulonephritis
  • Potential for overlapping diagnoses with nephrotic syndrome

Audit Risk Factors

  • Inadequate documentation of renal biopsy results
  • Failure to specify the type of nephritic syndrome
  • Misclassification of nephrotic vs. nephritic syndrome
  • Lack of follow-up documentation on treatment response

Specialty Focus

Medical Specialties

Nephrology

Documentation Requirements

Detailed clinical notes on symptoms, lab results, and biopsy findings.

Common Clinical Scenarios

Patients presenting with hematuria, proteinuria, and renal impairment.

Billing Considerations

Ensure clarity in distinguishing between nephritic and nephrotic syndromes.

Pathology

Documentation Requirements

Comprehensive reports on renal biopsy findings, including histological details.

Common Clinical Scenarios

Biopsy evaluations for patients with suspected glomerulonephritis.

Billing Considerations

Accurate description of mesangial proliferation and other histological features.

Coding Guidelines

Inclusion Criteria

Use N05.3 When
  • Follow official ICD
  • CM guidelines for coding nephritic syndrome
  • Ensure that documentation supports the diagnosis, including clinical findings and any relevant laboratory or imaging studies

Exclusion Criteria

Do NOT use N05.3 When
  • Exclude conditions that may mimic nephritic syndrome

Related ICD-10 Codes

Related CPT Codes

88172CPT Code

Renal biopsy, percutaneous, needle

Clinical Scenario

Used when a renal biopsy is performed to confirm the diagnosis of nephritic syndrome.

Documentation Requirements

Biopsy report detailing histological findings and clinical correlation.

Specialty Considerations

Nephrologists must ensure that the biopsy is justified based on clinical indications.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of nephritic syndromes, improving the accuracy of diagnoses and treatment tracking. N05.3 provides a clear classification for unspecified nephritic syndrome, facilitating better management and research.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of nephritic syndromes, improving the accuracy of diagnoses and treatment tracking. N05.3 provides a clear classification for unspecified nephritic syndrome, facilitating better management and research.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of nephritic syndromes, improving the accuracy of diagnoses and treatment tracking. N05.3 provides a clear classification for unspecified nephritic syndrome, facilitating better management and research.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What are the key symptoms of nephritic syndrome?

Key symptoms include hematuria, proteinuria, hypertension, and edema. Patients may also experience fatigue and renal impairment.

How is diffuse mesangial proliferative glomerulonephritis diagnosed?

Diagnosis is typically made through renal biopsy, which reveals increased mesangial cell proliferation and may be accompanied by clinical symptoms of nephritic syndrome.