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ICD-10 Guide
ICD-10 CodesN14.2

N14.2

Billable

Nephropathy induced by unspecified drug, medicament or biological substance

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/18/2025

Code Description

ICD-10 N14.2 is a billable code used to indicate a diagnosis of nephropathy induced by unspecified drug, medicament or biological substance.

Key Diagnostic Point:

Nephropathy induced by unspecified drug, medicament or biological substance refers to kidney damage resulting from exposure to a drug or biological agent that is not specifically identified. This condition can manifest in various forms, including drug-induced interstitial nephritis, pyelonephritis, and hydronephrosis. The pathophysiology often involves an immune-mediated response or direct tubular toxicity, leading to inflammation and impaired renal function. Patients may present with symptoms such as flank pain, fever, and changes in urination patterns, often accompanied by urinary tract infections (UTIs). Diagnosis typically involves a combination of clinical evaluation, laboratory tests, and imaging studies to assess kidney function and structure. Management may include discontinuation of the offending agent, supportive care, and in some cases, antibiotic therapy to address secondary infections. Understanding the specific drug involved, if possible, is crucial for effective treatment and prevention of further nephrotoxicity.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of potential drugs causing nephropathy
  • Need for thorough patient history to identify drug exposure
  • Differentiation from other types of nephropathy
  • Potential for overlapping symptoms with other renal conditions

Audit Risk Factors

  • Inadequate documentation of drug history
  • Failure to specify the type of nephropathy
  • Misclassification of nephropathy type
  • Lack of supporting clinical evidence for diagnosis

Specialty Focus

Medical Specialties

Nephrology

Documentation Requirements

Detailed patient history including medication use, lab results, and imaging studies.

Common Clinical Scenarios

Patients presenting with acute kidney injury following medication changes or new prescriptions.

Billing Considerations

Ensure clear documentation of the timeline of drug exposure and renal function tests.

Infectious Disease

Documentation Requirements

Documentation of any urinary tract infections and their management.

Common Clinical Scenarios

Patients with recurrent UTIs and renal impairment potentially linked to antibiotic use.

Billing Considerations

Document the relationship between antibiotic use and renal function changes.

Coding Guidelines

Inclusion Criteria

Use N14.2 When
  • Follow official ICD
  • CM coding guidelines, ensuring accurate documentation of the patient's drug history and clinical findings
  • Include any relevant lab results and imaging studies to support the diagnosis

Exclusion Criteria

Do NOT use N14.2 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

81002CPT Code

Urinalysis, by dipstick or tablet reagent

Clinical Scenario

Used to evaluate renal function and detect urinary tract infections in patients with suspected nephropathy.

Documentation Requirements

Document the reason for urinalysis and any relevant findings.

Specialty Considerations

Nephrologists may require more detailed lab results to assess kidney function.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of nephropathy types, improving the accuracy of data collection and reimbursement processes. N14.2 provides a mechanism to capture cases where the drug is unspecified, which was less clearly defined in ICD-9.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of nephropathy types, improving the accuracy of data collection and reimbursement processes. N14.2 provides a mechanism to capture cases where the drug is unspecified, which was less clearly defined in ICD-9.

Reimbursement & Billing Impact

reimbursement processes. N14.2 provides a mechanism to capture cases where the drug is unspecified, which was less clearly defined in ICD-9.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What should I document to support the use of N14.2?

Document the patient's complete medication history, any recent changes in medications, clinical symptoms, laboratory results, and imaging studies that indicate nephropathy.