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ICD-10 Guide
ICD-10 CodesN46.01

N46.01

Billable

Organic azoospermia

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/18/2025

Code Description

ICD-10 N46.01 is a billable code used to indicate a diagnosis of organic azoospermia.

Key Diagnostic Point:

Organic azoospermia is a condition characterized by the complete absence of sperm in the ejaculate due to intrinsic testicular dysfunction. This condition can arise from various underlying causes, including genetic abnormalities, hormonal imbalances, or damage to the testicular tissue. Unlike obstructive azoospermia, where sperm production is normal but obstructed from reaching the ejaculate, organic azoospermia indicates a failure in sperm production itself. Common causes include Klinefelter syndrome, Y chromosome microdeletions, and exposure to environmental toxins. Patients may present with symptoms of male infertility, and a thorough evaluation often includes hormonal assays, genetic testing, and testicular biopsy. Management may involve assisted reproductive technologies, such as sperm retrieval techniques, and hormonal treatments to address underlying issues. Understanding the etiology of organic azoospermia is crucial for effective treatment and counseling regarding fertility options.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Differentiation between obstructive and non-obstructive azoospermia
  • Need for comprehensive diagnostic testing
  • Potential for multiple underlying causes
  • Variability in treatment approaches based on etiology

Audit Risk Factors

  • Inadequate documentation of diagnostic tests performed
  • Failure to specify the type of azoospermia
  • Lack of correlation between clinical findings and coding
  • Misclassification of obstructive vs. organic azoospermia

Specialty Focus

Medical Specialties

Urology

Documentation Requirements

Detailed history of infertility, physical examination findings, and results of hormonal and genetic testing.

Common Clinical Scenarios

Evaluation of male infertility, management of testicular disorders, and treatment planning for assisted reproductive technologies.

Billing Considerations

Ensure clear documentation of the diagnostic process and treatment options discussed with the patient.

Endocrinology

Documentation Requirements

Hormonal assay results, assessment of endocrine function, and any relevant imaging studies.

Common Clinical Scenarios

Assessment of hormonal imbalances contributing to azoospermia and management of related endocrine disorders.

Billing Considerations

Document any hormonal therapies initiated and their impact on fertility.

Coding Guidelines

Inclusion Criteria

Use N46.01 When
  • Follow the official ICD
  • CM coding guidelines, ensuring accurate documentation of the diagnosis and any associated conditions
  • Include any relevant diagnostic tests and treatments in the medical record to support the coding

Exclusion Criteria

Do NOT use N46.01 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

89258CPT Code

Semen analysis, sperm count

Clinical Scenario

Used to confirm the diagnosis of azoospermia.

Documentation Requirements

Document the results of the semen analysis and any relevant patient history.

Specialty Considerations

Urologists should ensure that the analysis is performed in a certified lab.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of azoospermia, enabling better tracking of infertility causes and treatment outcomes. This specificity aids in research and improves patient care by allowing for tailored treatment plans.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of azoospermia, enabling better tracking of infertility causes and treatment outcomes. This specificity aids in research and improves patient care by allowing for tailored treatment plans.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of azoospermia, enabling better tracking of infertility causes and treatment outcomes. This specificity aids in research and improves patient care by allowing for tailored treatment plans.

Resources

Clinical References

  • •
    American Urological Association Guidelines

Coding & Billing References

  • •
    American Urological Association Guidelines

Frequently Asked Questions

What is the difference between organic and obstructive azoospermia?

Organic azoospermia is due to intrinsic testicular dysfunction, while obstructive azoospermia occurs when sperm production is normal but blocked from reaching the ejaculate.