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ICD-10 Guide
ICD-10 CodesN48.33

N48.33

Billable

Priapism, drug-induced

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/18/2025

Code Description

ICD-10 N48.33 is a billable code used to indicate a diagnosis of priapism, drug-induced.

Key Diagnostic Point:

Priapism is a prolonged and often painful erection that lasts for more than four hours and occurs without sexual stimulation. Drug-induced priapism can result from various medications, including those used for erectile dysfunction, antipsychotics, and anticoagulants. The condition can lead to significant complications, including erectile dysfunction and penile tissue damage if not treated promptly. The pathophysiology involves impaired venous outflow from the penis, leading to engorgement of the erectile tissues. Clinicians must differentiate between ischemic and non-ischemic priapism, as the management strategies differ significantly. Ischemic priapism, which is more common in drug-induced cases, requires urgent intervention to prevent irreversible damage. Treatment may involve aspiration of blood from the corpora cavernosa, administration of sympathomimetic agents, or surgical intervention in severe cases. Understanding the underlying cause, including medication history, is crucial for effective management and prevention of recurrence.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of medications that can cause priapism
  • Need for differentiation between ischemic and non-ischemic priapism
  • Potential for serious complications if not coded correctly
  • Documentation of medication history and patient symptoms

Audit Risk Factors

  • Inadequate documentation of medication history
  • Failure to specify the type of priapism
  • Lack of clinical correlation between symptoms and diagnosis
  • Inconsistent coding of related conditions

Specialty Focus

Medical Specialties

Urology

Documentation Requirements

Detailed history of presenting symptoms, medication list, and treatment response.

Common Clinical Scenarios

Patients presenting with prolonged erections after starting new medications, or those with a history of priapism.

Billing Considerations

Urologists must document the urgency of treatment and any interventions performed.

Psychiatry

Documentation Requirements

Comprehensive medication management records, including psychotropic medications that may induce priapism.

Common Clinical Scenarios

Patients on antipsychotic medications presenting with priapism.

Billing Considerations

Psychiatrists should be aware of the potential side effects of medications and document any changes in treatment.

Coding Guidelines

Inclusion Criteria

Use N48.33 When
  • 10 guidelines specify that N48
  • 33 should be used when priapism is directly linked to drug use
  • Documentation must clearly indicate the causative medication and the duration of the episode

Exclusion Criteria

Do NOT use N48.33 When
  • Exclusion criteria include priapism due to other causes, such as trauma or hematological disorders

Related ICD-10 Codes

Related CPT Codes

54050CPT Code

Aspiration of the corpora cavernosa

Clinical Scenario

Used in cases of ischemic priapism to relieve symptoms.

Documentation Requirements

Document the procedure performed, indication, and patient response.

Specialty Considerations

Urologists must ensure proper coding for the procedure based on the diagnosis.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of priapism, including the identification of drug-induced cases. This specificity aids in better tracking of treatment outcomes and complications.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of priapism, including the identification of drug-induced cases. This specificity aids in better tracking of treatment outcomes and complications.

Reimbursement & Billing Impact

reimbursement.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What medications are commonly associated with drug-induced priapism?

Medications such as trazodone, certain antipsychotics (like clozapine), and anticoagulants are commonly associated with drug-induced priapism. It's important to review the patient's medication history thoroughly.