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ICD-10 Guide
ICD-10 CodesN91.1

N91.1

Billable

Secondary amenorrhea

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/18/2025

Code Description

ICD-10 N91.1 is a billable code used to indicate a diagnosis of secondary amenorrhea.

Key Diagnostic Point:

Secondary amenorrhea is defined as the absence of menstruation for three consecutive cycles or for six months in women who have previously menstruated regularly. This condition can arise from various physiological and pathological factors, including hormonal imbalances, stress, significant weight loss or gain, excessive exercise, and underlying medical conditions such as polycystic ovary syndrome (PCOS), thyroid disorders, or pituitary tumors. Secondary amenorrhea can also be a consequence of lifestyle factors, such as the use of certain medications, contraceptives, or the impact of chronic illnesses. It is essential for healthcare providers to conduct a thorough evaluation to determine the underlying cause, which may involve hormonal testing, imaging studies, and a detailed patient history. Treatment options vary based on the etiology and may include lifestyle modifications, hormonal therapy, or addressing any underlying health issues. Understanding the multifactorial nature of secondary amenorrhea is crucial for effective management and restoration of normal menstrual function.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of potential underlying causes requiring thorough documentation.
  • Need for detailed patient history to establish prior menstrual patterns.
  • Differentiation from primary amenorrhea and other menstrual disorders.
  • Potential overlap with other conditions affecting reproductive health.

Audit Risk Factors

  • Inadequate documentation of menstrual history.
  • Failure to specify the underlying cause of amenorrhea.
  • Lack of supporting diagnostic tests in the medical record.
  • Misclassification of secondary amenorrhea as primary.

Specialty Focus

Medical Specialties

Obstetrics and Gynecology

Documentation Requirements

Detailed menstrual history, physical examination findings, and results of any diagnostic tests.

Common Clinical Scenarios

Patients presenting with missed periods, weight changes, or stress-related amenorrhea.

Billing Considerations

Ensure documentation reflects the timeline of amenorrhea and any associated symptoms.

Endocrinology

Documentation Requirements

Thorough evaluation of hormonal levels and potential endocrine disorders.

Common Clinical Scenarios

Patients with suspected hormonal imbalances or thyroid dysfunction presenting with amenorrhea.

Billing Considerations

Document any endocrine evaluations and their results to support the diagnosis.

Coding Guidelines

Inclusion Criteria

Use N91.1 When
  • According to ICD
  • 10 coding guidelines, secondary amenorrhea should be coded when the absence of menstruation is confirmed and documented
  • It is essential to include any relevant underlying conditions that may contribute to the amenorrhea

Exclusion Criteria

Do NOT use N91.1 When
  • Exclusion criteria include primary amenorrhea and amenorrhea due to pregnancy

Related ICD-10 Codes

Related CPT Codes

99213CPT Code

Established patient office visit, Level 3

Clinical Scenario

Used for follow-up visits to discuss amenorrhea and treatment options.

Documentation Requirements

Document the patient's history, examination findings, and treatment plan.

Specialty Considerations

Obstetricians should ensure they capture all relevant details regarding menstrual history.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of secondary amenorrhea, improving the ability to capture the nuances of the condition and its underlying causes, which can enhance patient care and treatment outcomes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of secondary amenorrhea, improving the ability to capture the nuances of the condition and its underlying causes, which can enhance patient care and treatment outcomes.

Reimbursement & Billing Impact

reimbursement.

Resources

Clinical References

  • •
    American College of Obstetricians and Gynecologists (ACOG)

Coding & Billing References

  • •
    American College of Obstetricians and Gynecologists (ACOG)

Frequently Asked Questions

What is the difference between primary and secondary amenorrhea?

Primary amenorrhea refers to the absence of menstruation in individuals who have never menstruated, while secondary amenorrhea is the absence of menstruation for three cycles or six months in individuals who have previously menstruated.