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ICD-10 Guide
ICD-10 CodesP61.2

P61.2

Billable

Anemia of prematurity

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 P61.2 is a billable code used to indicate a diagnosis of anemia of prematurity.

Key Diagnostic Point:

Anemia of prematurity (AOP) is a common hematological disorder in preterm infants, characterized by a decrease in hemoglobin concentration and red blood cell mass. This condition arises due to several factors, including inadequate erythropoiesis, shortened red blood cell lifespan, and blood loss from frequent laboratory testing. Premature infants often have lower levels of erythropoietin, a hormone that stimulates red blood cell production, which contributes to the development of anemia. Clinical manifestations may include pallor, lethargy, and poor feeding. Management typically involves supportive care, including iron supplementation and, in some cases, blood transfusions. Understanding the pathophysiology of AOP is crucial for effective management and coding, as it often coexists with other conditions such as thrombocytopenia and polycythemia, which can complicate the clinical picture and coding process.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between anemia of prematurity and other types of anemia.
  • Co-occurrence with other hematological disorders like thrombocytopenia and polycythemia.
  • Variability in clinical presentation based on gestational age.
  • Need for precise documentation of laboratory results and treatment interventions.

Audit Risk Factors

  • Inadequate documentation of laboratory values.
  • Failure to specify the gestational age of the infant.
  • Misclassification of anemia types.
  • Lack of clarity in treatment plans and interventions.

Specialty Focus

Medical Specialties

Neonatology

Documentation Requirements

Detailed records of hemoglobin levels, erythropoietin levels, and transfusion history.

Common Clinical Scenarios

Management of preterm infants with low hemoglobin levels in the NICU.

Billing Considerations

Consideration of gestational age and weight in treatment decisions.

Pediatrics

Documentation Requirements

Comprehensive history of perinatal conditions and follow-up care.

Common Clinical Scenarios

Assessment of anemia in infants with a history of prematurity.

Billing Considerations

Monitoring for long-term effects of anemia on growth and development.

Coding Guidelines

Inclusion Criteria

Use P61.2 When
  • Follow the ICD
  • CM guidelines for coding anemia, ensuring accurate documentation of the infant's gestational age and any associated conditions
  • Use additional codes as necessary to capture the full clinical picture

Exclusion Criteria

Do NOT use P61.2 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

36415CPT Code

Collection of venous blood by venipuncture

Clinical Scenario

Used frequently in monitoring hemoglobin levels in preterm infants.

Documentation Requirements

Document the reason for blood draws and results.

Specialty Considerations

Neonatologists should ensure minimal blood loss during testing.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of anemia types, improving the accuracy of diagnoses and treatment tracking in neonatal care.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of anemia types, improving the accuracy of diagnoses and treatment tracking in neonatal care.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of anemia types, improving the accuracy of diagnoses and treatment tracking in neonatal care.

Resources

Clinical References

  • •
    American Academy of Pediatrics - Neonatal Anemia Guidelines

Coding & Billing References

  • •
    American Academy of Pediatrics - Neonatal Anemia Guidelines

Frequently Asked Questions

What is the primary cause of anemia of prematurity?

The primary cause of anemia of prematurity is the combination of inadequate erythropoiesis due to immature hematopoietic systems and increased red blood cell destruction, often exacerbated by blood loss from frequent laboratory testing.