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ICD-10 Guide
ICD-10 CodesP74.6

P74.6

Billable

Transitory hyperammonemia of newborn

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 P74.6 is a billable code used to indicate a diagnosis of transitory hyperammonemia of newborn.

Key Diagnostic Point:

Transitory hyperammonemia of the newborn is a metabolic disturbance characterized by elevated levels of ammonia in the blood, typically occurring in the first few days of life. This condition is often transient and can result from various factors, including immature liver function, dietary protein intake, or metabolic disorders. In neonates, the liver is still developing its enzymatic pathways, which can lead to temporary disruptions in ammonia metabolism. Clinically, affected infants may present with lethargy, poor feeding, vomiting, or irritability. Diagnosis is confirmed through blood tests measuring ammonia levels. Management usually involves supportive care, including hydration and dietary adjustments, and the condition often resolves as the infant matures. However, close monitoring is essential to prevent potential neurological damage associated with prolonged hyperammonemia. Understanding the underlying causes and ensuring timely intervention are critical in managing this condition effectively.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in clinical presentation among neonates
  • Need for precise laboratory results to confirm diagnosis
  • Differentiation from other metabolic disorders
  • Documentation of transient nature and resolution

Audit Risk Factors

  • Inadequate documentation of clinical symptoms
  • Failure to note transient nature of the condition
  • Misclassification with chronic metabolic disorders
  • Lack of follow-up documentation on resolution

Specialty Focus

Medical Specialties

Neonatology

Documentation Requirements

Detailed clinical notes on symptoms, lab results, and management plans.

Common Clinical Scenarios

Infants presenting with lethargy and poor feeding in the NICU, requiring ammonia level monitoring.

Billing Considerations

Ensure documentation reflects the transient nature and resolution of hyperammonemia.

Pediatrics

Documentation Requirements

Comprehensive history and physical examination notes, including dietary intake and metabolic assessments.

Common Clinical Scenarios

Pediatric follow-up for infants previously diagnosed with hyperammonemia, monitoring growth and development.

Billing Considerations

Consider potential long-term effects on neurodevelopment and document any interventions.

Coding Guidelines

Inclusion Criteria

Use P74.6 When
  • Follow the ICD
  • CM guidelines for coding metabolic disorders, ensuring accurate documentation of the condition's transient nature and any associated symptoms or treatments

Exclusion Criteria

Do NOT use P74.6 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

36415CPT Code

Venipuncture for blood draw

Clinical Scenario

Used to obtain blood samples for ammonia level testing in newborns.

Documentation Requirements

Document the reason for blood draw and any relevant clinical findings.

Specialty Considerations

Ensure proper technique and documentation of the procedure in neonatology.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of metabolic disorders, including transitory hyperammonemia, improving the accuracy of diagnoses and treatment tracking.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of metabolic disorders, including transitory hyperammonemia, improving the accuracy of diagnoses and treatment tracking.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of metabolic disorders, including transitory hyperammonemia, improving the accuracy of diagnoses and treatment tracking.

Resources

Clinical References

  • •
    American Academy of Pediatrics - Neonatal Hyperammonemia

Coding & Billing References

  • •
    American Academy of Pediatrics - Neonatal Hyperammonemia

Frequently Asked Questions

What are the common causes of transitory hyperammonemia in newborns?

Common causes include immature liver function, dietary protein intake, and transient metabolic disturbances. It is essential to monitor ammonia levels and provide supportive care.