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v1.0.0
ICD-10 Guide
ICD-10 CodesR74.9

R74.9

Abnormal serum enzyme level, unspecified

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R74.9 is a billable code used to indicate a diagnosis of abnormal serum enzyme level, unspecified.

Key Diagnostic Point:

R74.9 is used to classify abnormal serum enzyme levels that are not specified in the clinical documentation. Serum enzymes are proteins that catalyze biochemical reactions and are often released into the bloodstream when tissues are damaged or diseased. Common enzymes measured include alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatine kinase (CK). Abnormal levels can indicate a variety of conditions, including liver disease, myocardial infarction, muscle disorders, and more. The unspecified nature of this code means that while an abnormal enzyme level has been identified, the specific enzyme or the underlying cause has not been documented, necessitating further investigation. Clinicians may order additional tests or imaging studies to determine the cause of the abnormality, and it is crucial for coders to ensure that the documentation supports the use of this code, as it may lead to further diagnostic coding.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Lack of specificity in documentation
  • Variety of potential underlying causes
  • Need for additional diagnostic testing
  • Potential overlap with other enzyme-related codes

Audit Risk Factors

  • Insufficient documentation to support the diagnosis
  • Use of unspecified codes without further investigation
  • Failure to link abnormal enzyme levels to clinical findings
  • Inconsistent coding practices among providers

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Clear documentation of the clinical context surrounding the abnormal enzyme level, including any symptoms, history, and follow-up plans.

Common Clinical Scenarios

Patients presenting with fatigue, jaundice, or unexplained abdominal pain may have abnormal enzyme levels requiring further evaluation.

Billing Considerations

Ensure that all relevant lab results are included in the medical record to support the diagnosis.

Emergency Medicine

Documentation Requirements

Detailed documentation of acute symptoms, lab results, and any immediate interventions taken.

Common Clinical Scenarios

Patients presenting with chest pain or acute abdominal pain may have abnormal enzyme levels indicating potential myocardial infarction or pancreatitis.

Billing Considerations

Rapid assessment and documentation are critical in emergency settings to justify the use of this code.

Coding Guidelines

Inclusion Criteria

Use R74.9 When
  • Coders should refer to the official ICD
  • CM coding guidelines, ensuring that the use of R74
  • 9 is supported by the documentation
  • It is essential to confirm that the abnormal enzyme level is not due to a more specific condition that can be coded

Exclusion Criteria

Do NOT use R74.9 When
No specific exclusions found.

Related CPT Codes

80050CPT Code

General health panel

Clinical Scenario

Used when a comprehensive metabolic panel is ordered, which may include enzyme levels.

Documentation Requirements

Ensure that the lab results are documented and linked to the clinical findings.

Specialty Considerations

Internal medicine may frequently order these panels for routine check-ups.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more detailed coding of conditions, but it has also introduced complexity with unspecified codes like R74.9. Coders must ensure that they are using the most specific codes available to avoid denials and ensure proper reimbursement.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more detailed coding of conditions, but it has also introduced complexity with unspecified codes like R74.9. Coders must ensure that they are using the most specific codes available to avoid denials and ensure proper reimbursement.

Reimbursement & Billing Impact

reimbursement.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

When should I use R74.9?

Use R74.9 when there is documentation of an abnormal serum enzyme level, but the specific enzyme or underlying condition has not been identified. Ensure that further diagnostic workup is planned or has been performed.