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v1.0.0
ICD-10 Guide
ICD-10 CodesR77.2

R77.2

Abnormality of alphafetoprotein

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R77.2 is a billable code used to indicate a diagnosis of abnormality of alphafetoprotein.

Key Diagnostic Point:

Abnormality of alphafetoprotein (AFP) refers to elevated or decreased levels of this glycoprotein in the serum, which is primarily produced by the fetal liver, yolk sac, and gastrointestinal tract. In adults, abnormal AFP levels can indicate various pathological conditions, including liver diseases such as hepatocellular carcinoma, germ cell tumors, and certain types of liver cirrhosis. Elevated AFP levels are often associated with malignancies, particularly in the context of liver cancer, while decreased levels may be observed in conditions such as Down syndrome during pregnancy. The clinical significance of abnormal AFP levels necessitates further investigation, including imaging studies and possibly biopsy, to determine the underlying cause. Monitoring AFP levels can also be crucial in assessing treatment response and disease progression in patients with known malignancies. Accurate interpretation of AFP levels requires a comprehensive understanding of the patient's clinical context, including history, symptoms, and associated laboratory findings.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of conditions associated with abnormal AFP levels
  • Need for correlation with clinical findings and imaging studies
  • Potential for misinterpretation of AFP levels in pregnancy
  • Differentiation between benign and malignant causes

Audit Risk Factors

  • Inadequate documentation of clinical context
  • Failure to link abnormal AFP levels to specific diagnoses
  • Misclassification of benign conditions as malignant
  • Inconsistent reporting of AFP levels in pregnancy

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Detailed patient history, physical examination findings, and correlation of AFP levels with imaging studies.

Common Clinical Scenarios

Evaluation of patients with suspected liver tumors or germ cell tumors.

Billing Considerations

Consideration of liver function tests and imaging results is essential for accurate coding.

Emergency Medicine

Documentation Requirements

Acute care documentation must include rationale for AFP testing and any immediate interventions.

Common Clinical Scenarios

Acute presentations of liver failure or suspected malignancy.

Billing Considerations

Rapid assessment and documentation of clinical findings are crucial in emergency settings.

Coding Guidelines

Inclusion Criteria

Use R77.2 When
  • Follow official ICD
  • CM coding guidelines, ensuring that the code is used only when there is documented evidence of abnormal AFP levels and that it is linked to a specific clinical diagnosis

Exclusion Criteria

Do NOT use R77.2 When
No specific exclusions found.

Related CPT Codes

84155CPT Code

Alphafetoprotein (AFP) test

Clinical Scenario

Used for monitoring patients with liver cancer or germ cell tumors.

Documentation Requirements

Document the reason for the AFP test and any relevant clinical findings.

Specialty Considerations

Oncology specialists may require more detailed documentation regarding the patient's cancer history.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of conditions related to abnormal AFP levels, improving the ability to track and analyze these cases in clinical practice.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of conditions related to abnormal AFP levels, improving the ability to track and analyze these cases in clinical practice.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of conditions related to abnormal AFP levels, improving the ability to track and analyze these cases in clinical practice.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What does an elevated AFP level indicate?

An elevated AFP level can indicate liver cancer, germ cell tumors, or liver cirrhosis, among other conditions. It is important to correlate AFP levels with clinical findings and imaging studies for accurate diagnosis.

Can AFP levels be elevated in pregnancy?

Yes, AFP levels are typically elevated during pregnancy. It is crucial to document the context of AFP testing in pregnant patients to avoid misclassification.