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ICD-10 Guide
ICD-10 CodesR77.8

R77.8

Other specified abnormalities of plasma proteins

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R77.8 is a billable code used to indicate a diagnosis of other specified abnormalities of plasma proteins.

Key Diagnostic Point:

R77.8 encompasses a range of abnormalities in plasma proteins that do not fit into more specific categories. Plasma proteins, including albumin, globulins, and fibrinogen, play crucial roles in maintaining oncotic pressure, transporting substances, and facilitating clotting. Abnormalities may manifest as altered levels of these proteins, which can indicate various underlying conditions such as liver disease, kidney disorders, inflammatory states, or malignancies. Symptoms may include edema, jaundice, or signs of bleeding, depending on the specific protein involved and the underlying pathology. Laboratory findings may reveal abnormal serum protein electrophoresis patterns, altered albumin/globulin ratios, or changes in coagulation profiles. Accurate diagnosis often requires correlating clinical findings with laboratory results and may necessitate further testing to identify the underlying cause of the abnormality.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of underlying conditions that can cause abnormalities.
  • Need for correlation between clinical findings and lab results.
  • Potential for overlapping symptoms with other conditions.
  • Variability in laboratory reference ranges.

Audit Risk Factors

  • Inadequate documentation of clinical findings.
  • Failure to specify the type of plasma protein abnormality.
  • Misinterpretation of lab results leading to incorrect coding.
  • Lack of correlation between diagnosis and treatment provided.

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Detailed patient history, physical examination findings, and lab results must be documented to support the diagnosis.

Common Clinical Scenarios

Patients presenting with unexplained edema, jaundice, or abnormal lab results during routine check-ups.

Billing Considerations

Consideration of chronic conditions such as liver cirrhosis or nephrotic syndrome that may lead to plasma protein abnormalities.

Emergency Medicine

Documentation Requirements

Acute care documentation must include immediate lab results and clinical assessments.

Common Clinical Scenarios

Patients with acute liver failure or severe infections presenting with abnormal coagulation profiles.

Billing Considerations

Rapid assessment and documentation of symptoms and lab findings are critical for timely intervention.

Coding Guidelines

Inclusion Criteria

Use R77.8 When
  • Follow official ICD
  • CM guidelines for coding and reporting, ensuring that the code reflects the specific abnormality and is supported by clinical documentation

Exclusion Criteria

Do NOT use R77.8 When
No specific exclusions found.

Related CPT Codes

84155CPT Code

Protein electrophoresis

Clinical Scenario

Used to evaluate plasma protein abnormalities.

Documentation Requirements

Document the reason for the test and correlate with clinical findings.

Specialty Considerations

Internal medicine and hematology often utilize this procedure for diagnosis.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of plasma protein abnormalities, improving the granularity of data for clinical and research purposes. R77.8 provides a means to capture abnormalities that do not fit neatly into other categories, enhancing the understanding of patient conditions.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of plasma protein abnormalities, improving the granularity of data for clinical and research purposes. R77.8 provides a means to capture abnormalities that do not fit neatly into other categories, enhancing the understanding of patient conditions.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of plasma protein abnormalities, improving the granularity of data for clinical and research purposes. R77.8 provides a means to capture abnormalities that do not fit neatly into other categories, enhancing the understanding of patient conditions.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What should I document to support the use of R77.8?

Document the specific abnormal lab findings, the clinical context, and any relevant patient history that supports the diagnosis of other specified abnormalities of plasma proteins.