ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesR78.4

R78.4

Finding of other drugs of addictive potential in blood

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R78.4 is a billable code used to indicate a diagnosis of finding of other drugs of addictive potential in blood.

Key Diagnostic Point:

R78.4 is used to classify laboratory findings indicating the presence of drugs with addictive potential in the bloodstream. This may include substances such as opioids, benzodiazepines, stimulants, and other psychoactive drugs not specifically categorized elsewhere. The detection of these substances can occur during routine screenings, toxicology tests, or in the context of evaluating a patient for substance use disorders. Clinicians may order these tests when patients present with symptoms of intoxication, withdrawal, or when there is a suspicion of substance misuse. The clinical implications of finding these substances can be significant, as they may guide treatment decisions, necessitate further evaluation for substance use disorders, and inform risk assessments for overdose or adverse drug interactions. Accurate documentation of the clinical context, including the reason for testing and any associated symptoms, is essential for proper coding and billing.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of substances that can be detected under this code
  • Need for precise documentation of clinical context
  • Potential overlap with other codes related to substance use
  • Variability in testing methods and interpretation of results

Audit Risk Factors

  • Inadequate documentation of the clinical rationale for testing
  • Failure to specify the substances detected
  • Misuse of the code for routine screenings without clinical indication
  • Inconsistent coding practices across providers

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Documentation should include the patient's history, reason for testing, and any symptoms related to substance use.

Common Clinical Scenarios

Patients presenting with unexplained symptoms, suspected overdose, or withdrawal symptoms.

Billing Considerations

Consideration of the patient's medication history and potential for polypharmacy.

Emergency Medicine

Documentation Requirements

Acute care documentation must detail the presenting symptoms, the urgency of testing, and any immediate interventions.

Common Clinical Scenarios

Patients presenting with altered mental status, respiratory depression, or other acute symptoms suggestive of substance use.

Billing Considerations

Rapid assessment and documentation are critical in emergency settings to ensure appropriate coding.

Coding Guidelines

Inclusion Criteria

Use R78.4 When
  • Follow the official ICD
  • CM coding guidelines, ensuring that the code is used only when there is a confirmed finding of drugs of addictive potential in blood, and that the clinical context is well documented

Exclusion Criteria

Do NOT use R78.4 When
No specific exclusions found.

Related CPT Codes

80305CPT Code

Drug test, qualitative, multiple drugs

Clinical Scenario

Used when performing a drug screening that may lead to the use of R78.4.

Documentation Requirements

Document the specific drugs tested and the results.

Specialty Considerations

Ensure that the testing method is appropriate for the substances being screened.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of findings related to drug use, improving the ability to track and manage substance use disorders effectively.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of findings related to drug use, improving the ability to track and manage substance use disorders effectively.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of findings related to drug use, improving the ability to track and manage substance use disorders effectively.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

When should R78.4 be used?

R78.4 should be used when laboratory tests confirm the presence of drugs with addictive potential in the blood, and the clinical context is documented.