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ICD-10 Guide
ICD-10 CodesR83.0

R83.0

Abnormal level of enzymes in cerebrospinal fluid

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R83.0 is a billable code used to indicate a diagnosis of abnormal level of enzymes in cerebrospinal fluid.

Key Diagnostic Point:

Abnormal levels of enzymes in cerebrospinal fluid (CSF) can indicate various underlying neurological conditions. Enzymes such as lactate dehydrogenase (LDH), creatine kinase (CK), and others may be elevated due to inflammation, infection, or other pathological processes affecting the central nervous system (CNS). Common symptoms associated with abnormal enzyme levels in CSF may include headache, fever, neck stiffness, and altered mental status. The presence of elevated enzymes can suggest conditions such as meningitis, encephalitis, or demyelinating diseases. A thorough clinical evaluation, including a detailed history and neurological examination, is essential for determining the underlying cause. Laboratory findings, including CSF analysis through lumbar puncture, are critical for diagnosis. Abnormal enzyme levels should be interpreted in conjunction with other CSF parameters, such as cell count, protein concentration, and glucose levels, to provide a comprehensive understanding of the patient's condition.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of potential underlying conditions
  • Need for comprehensive CSF analysis
  • Interpretation of enzyme levels in context
  • Differentiation from other neurological disorders

Audit Risk Factors

  • Inadequate documentation of clinical findings
  • Failure to correlate enzyme levels with symptoms
  • Misinterpretation of CSF analysis results
  • Coding without sufficient clinical context

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Detailed patient history, neurological examination findings, and rationale for lumbar puncture.

Common Clinical Scenarios

Patients presenting with unexplained neurological symptoms, requiring CSF analysis for diagnosis.

Billing Considerations

Ensure correlation between clinical symptoms and laboratory findings to support the diagnosis.

Emergency Medicine

Documentation Requirements

Acute care documentation including vital signs, neurological status, and immediate interventions.

Common Clinical Scenarios

Patients with acute onset of neurological symptoms, such as severe headache or altered mental status, necessitating rapid CSF analysis.

Billing Considerations

Document the urgency of the situation and the rationale for immediate CSF analysis.

Coding Guidelines

Inclusion Criteria

Use R83.0 When
  • Follow official ICD
  • CM coding guidelines, ensuring that the code is used only when there is clear documentation of abnormal enzyme levels in CSF and relevant clinical context

Exclusion Criteria

Do NOT use R83.0 When
No specific exclusions found.

Related CPT Codes

62270CPT Code

Lumbar puncture

Clinical Scenario

Used to obtain CSF for analysis when abnormal enzyme levels are suspected.

Documentation Requirements

Document indication for lumbar puncture, patient consent, and procedure details.

Specialty Considerations

Ensure compliance with procedural guidelines and documentation standards.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of abnormal findings in CSF, improving the ability to capture the nuances of neurological conditions and their management.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of abnormal findings in CSF, improving the ability to capture the nuances of neurological conditions and their management.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of abnormal findings in CSF, improving the ability to capture the nuances of neurological conditions and their management.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What are the common causes of abnormal enzyme levels in CSF?

Common causes include infections (such as meningitis), autoimmune disorders, traumatic brain injury, and demyelinating diseases.