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ICD-10 Guide
ICD-10 CodesR83.2

R83.2

Abnormal level of other drugs, medicaments and biological substances in cerebrospinal fluid

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R83.2 is a billable code used to indicate a diagnosis of abnormal level of other drugs, medicaments and biological substances in cerebrospinal fluid.

Key Diagnostic Point:

R83.2 refers to the abnormal levels of drugs, medicaments, and biological substances found in the cerebrospinal fluid (CSF). This condition can indicate various underlying issues, including drug toxicity, therapeutic drug monitoring, or the presence of biological agents such as antibodies or proteins associated with neurological disorders. Symptoms may vary widely depending on the substance involved and the underlying condition, but can include neurological deficits, altered mental status, seizures, or signs of infection. Abnormal findings in CSF can arise from various causes, including drug overdoses, infections, autoimmune diseases, or malignancies. Accurate diagnosis often requires a combination of clinical evaluation, laboratory testing, and imaging studies to determine the cause of the abnormal findings and guide appropriate treatment.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of substances that can be involved
  • Need for precise laboratory results
  • Differential diagnosis complexity
  • Potential overlap with other neurological conditions

Audit Risk Factors

  • Inadequate documentation of clinical findings
  • Failure to specify the substance involved
  • Misinterpretation of laboratory results
  • Inconsistent coding of related neurological conditions

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Detailed patient history, including medication use and symptoms, along with lab results.

Common Clinical Scenarios

Patients presenting with neurological symptoms and a history of medication use.

Billing Considerations

Ensure comprehensive documentation of all medications and biological substances that may affect CSF levels.

Emergency Medicine

Documentation Requirements

Acute care notes, including rapid assessment of neurological status and immediate lab results.

Common Clinical Scenarios

Patients with altered mental status or seizures requiring urgent evaluation of CSF.

Billing Considerations

Document the urgency of the situation and any immediate interventions performed.

Coding Guidelines

Inclusion Criteria

Use R83.2 When
  • Follow official ICD
  • 10 coding guidelines, ensuring that the code is used only when there is clear documentation of abnormal levels in CSF and that the clinical context supports the diagnosis

Exclusion Criteria

Do NOT use R83.2 When
No specific exclusions found.

Related CPT Codes

62270CPT Code

Lumbar puncture

Clinical Scenario

Used to obtain CSF for analysis when abnormal levels are suspected.

Documentation Requirements

Document the indication for the procedure and the findings from CSF analysis.

Specialty Considerations

In neurology, ensure that the rationale for lumbar puncture is clearly documented.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of abnormal findings in CSF, improving the accuracy of diagnoses and treatment tracking.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of abnormal findings in CSF, improving the accuracy of diagnoses and treatment tracking.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of abnormal findings in CSF, improving the accuracy of diagnoses and treatment tracking.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What types of substances can lead to R83.2 coding?

R83.2 can be used for abnormal levels of various drugs, including opioids, antibiotics, and biological agents like antibodies or proteins associated with neurological disorders.