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ICD-10 Guide
ICD-10 CodesR85.610

R85.610

Atypical squamous cells of undetermined significance on cytologic smear of anus (ASC-US)

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R85.610 is a billable code used to indicate a diagnosis of atypical squamous cells of undetermined significance on cytologic smear of anus (asc-us).

Key Diagnostic Point:

Atypical squamous cells of undetermined significance (ASC-US) on a cytologic smear of the anus indicate the presence of abnormal squamous cells that do not meet the criteria for a definitive diagnosis of malignancy or a specific benign condition. This finding is often encountered during routine screening procedures, such as anal Pap smears, which are performed to detect precancerous changes or anal cancer. ASC-US can arise from various causes, including inflammation, infection (such as HPV), or reactive changes due to trauma or irritation. The clinical significance of ASC-US is uncertain, necessitating further evaluation to rule out high-grade lesions or malignancy. Patients may be asymptomatic, or they may present with symptoms such as anal discomfort, bleeding, or changes in bowel habits. Follow-up typically involves repeat cytology, HPV testing, or biopsy to clarify the diagnosis and guide management.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in clinical presentation and symptoms
  • Need for follow-up testing and interpretation of results
  • Differentiation from other abnormal findings
  • Potential for misdiagnosis if not properly evaluated

Audit Risk Factors

  • Inadequate documentation of follow-up plans
  • Failure to specify the reason for the cytology test
  • Misclassification of ASC-US as a definitive diagnosis
  • Lack of patient history related to risk factors

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Documentation should include the reason for the cytologic smear, patient history, and any symptoms present.

Common Clinical Scenarios

Routine screening in asymptomatic patients or evaluation of symptomatic patients with anal discomfort.

Billing Considerations

Consideration of risk factors such as HIV status, history of anal warts, or previous abnormal smears.

Emergency Medicine

Documentation Requirements

Acute care documentation should include presenting symptoms, any immediate interventions, and follow-up plans.

Common Clinical Scenarios

Patients presenting with anal bleeding or discomfort requiring urgent evaluation.

Billing Considerations

Rapid assessment of symptoms to rule out other acute conditions such as anal fissures or abscesses.

Coding Guidelines

Inclusion Criteria

Use R85.610 When
  • Follow the official ICD
  • CM coding guidelines, ensuring that the code is used only when ASC
  • US is confirmed by cytology and that appropriate follow
  • up is documented

Exclusion Criteria

Do NOT use R85.610 When
No specific exclusions found.

Related CPT Codes

88141CPT Code

Cytopathology, cervical or vaginal, liquid-based preparation

Clinical Scenario

Used when performing a liquid-based cytology test for ASC-US.

Documentation Requirements

Document the type of preparation and the results of the cytology.

Specialty Considerations

Ensure that the procedure is linked to the diagnosis of ASC-US.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of atypical findings, improving the accuracy of data collection and patient management.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of atypical findings, improving the accuracy of data collection and patient management.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of atypical findings, improving the accuracy of data collection and patient management.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What does ASC-US mean?

ASC-US stands for atypical squamous cells of undetermined significance, indicating abnormal cells that require further evaluation.

How is ASC-US diagnosed?

ASC-US is diagnosed through cytologic examination of anal smears, often during routine screening.

What are the follow-up procedures for ASC-US?

Follow-up may include repeat cytology, HPV testing, or biopsy to determine the significance of the findings.