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ICD-10 Guide
ICD-10 CodesR89.0

R89.0

Abnormal level of enzymes in specimens from other organs, systems and tissues

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R89.0 is a billable code used to indicate a diagnosis of abnormal level of enzymes in specimens from other organs, systems and tissues.

Key Diagnostic Point:

R89.0 is used to classify abnormal enzyme levels detected in specimens derived from various organs, systems, or tissues that do not fall under more specific categories. Enzymes are proteins that catalyze biochemical reactions in the body, and their abnormal levels can indicate underlying pathological processes. Commonly tested enzymes include liver enzymes (e.g., AST, ALT), cardiac enzymes (e.g., troponin), and pancreatic enzymes (e.g., amylase, lipase). Abnormal levels may arise from a variety of conditions, including liver disease, myocardial infarction, pancreatitis, and muscle disorders. The clinical significance of these findings often necessitates further investigation to determine the underlying cause, which may involve additional laboratory tests, imaging studies, or specialist referrals. Accurate coding of R89.0 requires careful consideration of the clinical context and documentation of the specific enzymes involved, as well as any associated symptoms or findings.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of enzymes and conditions that can lead to abnormal levels
  • Need for precise documentation of the specific enzyme tested
  • Potential overlap with other codes for specific enzyme abnormalities
  • Variability in clinical significance based on patient history and presentation

Audit Risk Factors

  • Inadequate documentation of the specific enzyme tested
  • Failure to correlate enzyme levels with clinical findings
  • Misuse of R89.0 when a more specific code is available
  • Lack of follow-up documentation for abnormal findings

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Detailed documentation of the patient's clinical history, symptoms, and specific enzyme levels tested.

Common Clinical Scenarios

Patients presenting with unexplained abdominal pain, fatigue, or other systemic symptoms prompting enzyme testing.

Billing Considerations

Consideration of comorbid conditions that may affect enzyme levels, such as liver disease or diabetes.

Emergency Medicine

Documentation Requirements

Acute care documentation must include the reason for enzyme testing and any immediate clinical findings.

Common Clinical Scenarios

Patients presenting with chest pain or acute abdominal pain requiring rapid assessment of enzyme levels.

Billing Considerations

Timeliness of documentation is critical in emergency settings to ensure accurate coding and billing.

Coding Guidelines

Inclusion Criteria

Use R89.0 When
  • Follow the official ICD
  • CM coding guidelines, ensuring that the code is used only when no more specific code is applicable
  • Document the clinical context and any relevant lab findings to support the use of R89

Exclusion Criteria

Do NOT use R89.0 When
No specific exclusions found.

Related CPT Codes

84450CPT Code

Liver enzyme panel

Clinical Scenario

Used when evaluating liver function in patients with symptoms of liver disease.

Documentation Requirements

Document the clinical indication for the liver enzyme panel and any relevant history.

Specialty Considerations

Internal medicine specialists should ensure correlation with clinical findings.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more detailed coding of enzyme abnormalities, improving specificity and accuracy in capturing clinical conditions.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more detailed coding of enzyme abnormalities, improving specificity and accuracy in capturing clinical conditions.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more detailed coding of enzyme abnormalities, improving specificity and accuracy in capturing clinical conditions.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

When should I use R89.0?

Use R89.0 when enzyme levels are abnormal and do not fit into a more specific category. Ensure that documentation supports the clinical context.