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v1.0.0
ICD-10 Guide
ICD-10 CodesZ15.8

Z15.8

Genetic susceptibility to other disease

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/12/2025

Code Description

ICD-10 Z15.8 is a billable code used to indicate a diagnosis of genetic susceptibility to other disease.

Key Diagnostic Point:

Z15.8 indicates a genetic predisposition to diseases that are not specified elsewhere in the ICD-10 coding system. This code is crucial for identifying patients who may be at increased risk for certain conditions due to their genetic makeup. Understanding genetic susceptibility can influence preventive care strategies, screening protocols, and aftercare management. Social determinants of health, such as socioeconomic status, education, and access to healthcare, play a significant role in how these patients engage with health services. Preventive measures may include genetic counseling, lifestyle modifications, and regular screenings tailored to the individual's risk profile. Documentation must reflect the patient's genetic background, any relevant family history, and the impact of social factors on their health status. This comprehensive approach ensures that healthcare providers can deliver personalized care and monitor at-risk populations effectively.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Requires detailed family history documentation
  • Involves understanding of genetic testing results
  • May necessitate interdisciplinary communication among healthcare providers
  • Varies based on the specific diseases being screened for

Audit Risk Factors

  • Inadequate documentation of genetic history
  • Failure to link genetic susceptibility to specific preventive measures
  • Misuse of the code without appropriate clinical context
  • Lack of follow-up documentation for aftercare

Specialty Focus

Medical Specialties

Primary Care

Documentation Requirements

Document family history, genetic counseling sessions, and preventive care plans.

Common Clinical Scenarios

Routine checkups where genetic risk factors are assessed, screenings for hereditary conditions.

Billing Considerations

Consider social determinants such as access to genetic testing and counseling services.

Public Health

Documentation Requirements

Population health data, genetic predisposition statistics, and community health assessments.

Common Clinical Scenarios

Epidemiological studies focusing on genetic risk factors in specific populations.

Billing Considerations

Tracking health outcomes related to genetic susceptibility in diverse communities.

Coding Guidelines

Inclusion Criteria

Use Z15.8 When
  • Z codes should be used when a patient has a genetic susceptibility that impacts their health status but is not the primary diagnosis
  • Proper sequencing is essential, and payers may have specific requirements for documentation of genetic counseling and preventive measures

Exclusion Criteria

Do NOT use Z15.8 When
No specific exclusions found.

Related CPT Codes

81200CPT Code

BRCA1 and BRCA2 gene analysis

Clinical Scenario

Used when a patient is tested for breast and ovarian cancer susceptibility.

Documentation Requirements

Document the reason for testing, family history, and results.

Specialty Considerations

Primary care providers should coordinate with genetic counselors.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for greater specificity in coding genetic susceptibilities, enabling better tracking and management of at-risk populations.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for greater specificity in coding genetic susceptibilities, enabling better tracking and management of at-risk populations.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for greater specificity in coding genetic susceptibilities, enabling better tracking and management of at-risk populations.

Resources

Clinical References

  • •
    Genetic Testing and Counseling Guidelines

Coding & Billing References

  • •
    Genetic Testing and Counseling Guidelines

Frequently Asked Questions

When should Z15.8 be used in clinical practice?

Z15.8 should be used when a patient has a documented genetic susceptibility that impacts their health status, particularly in the context of preventive care and screenings.