ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
DiagnosesAcute Kidney Injury Due To Immunotherapy

Acute Kidney Injury Due To Immunotherapy

ICD-10 Coding for Acute Kidney Injury due to Immunotherapy(N17.9, N14.1)

PRIMARY SPECIALTYOncology
COMPLEXITYHigh
LAST UPDATED09/15/2025
Sam Tuffun, PT, DPT
Physical Therapist | Medical Coding & Billing Contributor

Diagnosis Overview

What is Acute Kidney Injury Due To Immunotherapy?
Essential facts and insights about Acute Kidney Injury due to Immunotherapy

Key Clinical Considerations:

  • Acute rise in serum creatinine levels, typically >0.3 mg/dL within 48 hours or >1.5 times baseline within the past 7 days.
  • Urinalysis showing signs of acute tubular injury, such as muddy brown casts or renal tubular epithelial cells.
  • Physical examination may reveal signs of volume overload, such as edema or hypertension.
  • Imaging studies (e.g., ultrasound) may show normal kidney size or signs of obstruction.
  • Severity criteria include staging based on serum creatinine levels and urine output (e.g., KDIGO classification).

Clinical Information

Clinical Criteria & Documentation Requirements

  • Document the onset and duration of symptoms, including any recent immunotherapy treatments.
  • Use specific terminology such as 'acute kidney injury' and 'immunotherapy-related nephrotoxicity'.
  • Examples include: 'Patient presents with acute kidney injury following administration of [specific immunotherapy agent]'.
  • Document medical necessity for tests and treatments related to kidney function monitoring.
  • Quality measures may include tracking serum creatinine levels and urine output in patients receiving immunotherapy.

Coding Guidelines

Usage Guidelines & Examples

  • Use N17.9 for unspecified acute kidney injury when the cause is not documented; use N14.1 when specifically due to immunotherapy.
  • Do not use N17.9 if the cause of acute kidney injury is clearly documented as due to other factors (e.g., dehydration, nephrotoxic drugs).
  • N14.1 is specifically for acute kidney injury due to immunotherapy, while N17.0-N17.8 cover other types of acute kidney injury.
  • Common errors include misclassifying acute kidney injury as chronic; ensure documentation supports acute diagnosis.
  • In complex cases, consider additional codes for underlying conditions or complications.

Code Exclusions

Important Exclusions

  • Exclude chronic kidney disease (N18) unless acute kidney injury is superimposed on chronic conditions.
  • Alternative codes for excluded conditions may include N17.0 for acute kidney failure due to other causes.
  • Conditions are excluded to ensure accurate representation of the cause of acute kidney injury.
  • Common mistakes include failing to document the specific cause of acute kidney injury, leading to incorrect coding.
  • Related but distinct conditions include acute tubular necrosis due to other nephrotoxins.

Related ICD-10 Codes

Primary Codes
N14.1
Acute kidney injury due to immunotherapy
N17.9
Acute kidney injury, unspecified
Ancillary Codes
T45.1X5A
Differential Codes
N17.0
N17.9
N17.9
if no specific histopathology is documented.

Related CPT Codes

CPT codes will be available in a future update.

Specialty Focus

Primary Specialty

Oncology

Specialty Applications

  • Patients undergoing cancer treatment with immunotherapy agents such as checkpoint inhibitors.
  • Typically affects adults, but can occur in any age group, especially those with pre-existing kidney conditions.
  • Clinical settings include inpatient oncology units, outpatient infusion centers, and emergency departments.
  • Oncology specialty applications are critical due to the rising use of immunotherapy in cancer treatment.
  • Treatment contexts include monitoring kidney function during and after immunotherapy administration.

Coding Complexity

High Complexity

This diagnosis requires careful attention to:

  • Comprehensive clinical documentation
  • Accurate code selection based on clinical criteria
  • Proper exclusion considerations
  • Specialty-specific coding guidelines

Documentation

Documentation Templates

Template 1

Template: 'Patient diagnosed with acute kidney injury due to immunotherapy based on elevated serum creatinine levels.'

Template 2

Template: 'Clinical presentation consistent with acute kidney injury including oliguria and elevated creatinine.'

Template 3

Template: 'Diagnostic criteria met as evidenced by serum creatinine >0.3 mg/dL following immunotherapy.'

Template 4

Template: 'Treatment plan initiated for acute kidney injury with hydration and monitoring of renal function.'

Template 5

Template: 'Follow-up care for acute kidney injury including regular monitoring of kidney parameters and adjustment of immunotherapy.'

Billing Information

Billing Considerations

  • Ensure proper documentation for billing
  • Verify code specificity requirements
  • Check for any additional codes needed
  • Review payer-specific guidelines

Common Issues

  • Insufficient clinical documentation
  • Incorrect code selection
  • Missing supporting diagnoses
  • Timing and frequency documentation

Frequently Asked Questions

What documentation is required for this diagnosis?

Documentation must include clinical findings, treatment history, and laboratory results.

How does this differ from similar diagnoses?

Differentiation is based on the specific cause of acute kidney injury, particularly related to immunotherapy.

What are common billing considerations?

Ensure that all treatments and tests are medically necessary and well-documented to optimize claims.

What procedures are typically associated?

Related CPT codes may include nephrology consultations and renal function tests.

Are there any quality reporting implications?

Quality measures may include monitoring kidney function and documenting any adverse effects of immunotherapy.