ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
DiagnosesAluminum Amyloid

Aluminum Amyloid

ICD-10 Coding for AL Amyloidosis(E85.81, E85.89)

PRIMARY SPECIALTYCardiology
COMPLEXITYHigh
LAST UPDATED09/15/2025
Sam Tuffun, PT, DPT
Physical Therapist | Medical Coding & Billing Contributor

Diagnosis Overview

What is Aluminum Amyloid?
Essential facts and insights about AL Amyloidosis

Key Clinical Considerations:

  • Presence of abnormal protein (amyloid) in tissues or organs
  • Positive Congo red staining for amyloid
  • Evidence of organ dysfunction due to amyloid deposition

Clinical Information

Clinical Criteria & Documentation Requirements

  • Detailed description of patient's symptoms and clinical findings
  • Results of diagnostic tests confirming amyloid deposition
  • Specific organs affected by amyloidosis

Coding Guidelines

Usage Guidelines & Examples

  • E85.81 is used for AL (primary) amyloidosis
  • E85.89 is used for other amyloidosis, not classified as AL

Code Exclusions

Important Exclusions

  • Secondary (AA) amyloidosis
  • Hereditary amyloidosis

Related ICD-10 Codes

Primary Codes
E85.81
Light chain (AL) amyloidosis
E85.89
Other amyloidosis
Ancillary Codes
N04.9
Differential Codes
E85.82
E85.81

Related CPT Codes

CPT codes will be available in a future update.

Specialty Focus

Primary Specialty

Cardiology

Specialty Applications

  • Patients with confirmed diagnosis of AL amyloidosis
  • Scenarios where amyloidosis is causing organ dysfunction

Coding Complexity

High Complexity

This diagnosis requires careful attention to:

  • Comprehensive clinical documentation
  • Accurate code selection based on clinical criteria
  • Proper exclusion considerations
  • Specialty-specific coding guidelines

Documentation

Documentation Templates

Template 1

Patient presents with [symptoms] consistent with AL amyloidosis.

Template 2

Diagnostic tests reveal [findings] indicative of AL amyloidosis affecting [organs].

Billing Information

Billing Considerations

  • Ensure proper documentation for billing
  • Verify code specificity requirements
  • Check for any additional codes needed
  • Review payer-specific guidelines

Common Issues

  • Insufficient clinical documentation
  • Incorrect code selection
  • Missing supporting diagnoses
  • Timing and frequency documentation

Frequently Asked Questions

What is the difference between E85.81 and E85.89?

E85.81 is specific for AL amyloidosis, while E85.89 is used for other forms of amyloidosis.

When should this code be used?

These codes should be used when a patient has a confirmed diagnosis of AL amyloidosis and it is relevant to the current phase of care.