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v1.0.0
ICD-10 Guide
DiagnosesHerpes Simplex Infection

Herpes Simplex Infection

ICD-10 Coding for Herpes Simplex Infection(B00.1, B00.2)

PRIMARY SPECIALTYNeurology
COMPLEXITYHigh
LAST UPDATED09/15/2025
Sam Tuffun, PT, DPT
Physical Therapist | Medical Coding & Billing Contributor

Diagnosis Overview

What is Herpes Simplex Infection?
Essential facts and insights about Herpes Simplex Infection

Key Clinical Considerations:

  • Recurrent vesicular lesions on the skin or mucous membranes
  • PCR testing for HSV DNA, serological tests for HSV antibodies
  • Neurological examination may reveal signs of meningitis or encephalitis

Clinical Information

Clinical Criteria & Documentation Requirements

  • Patient history of herpes simplex infections, clinical findings, and treatment plan
  • Use of specific ICD-10 codes for herpes simplex infections
  • Examples include documenting the location of lesions and any neurological symptoms

Coding Guidelines

Usage Guidelines & Examples

  • Follow usage guidelines for differentiating between primary and recurrent infections.
  • Common errors include misclassifying the type of herpes infection.

Code Exclusions

Important Exclusions

  • Other viral infections that may mimic herpes simplex symptoms
  • Alternative codes for other types of herpes infections (e.g., varicella-zoster virus)

Related ICD-10 Codes

Primary Codes
B00.1
Herpes simplex encephalitis
B00.2
Herpes simplex virus infection, unspecified
Ancillary Codes
Z11.3
Differential Codes
R20.2
K12.0

Related CPT Codes

CPT codes will be available in a future update.

Specialty Focus

Primary Specialty

Neurology

Specialty Applications

  • Patients with a history of herpes simplex infections, particularly those with neurological symptoms
  • Neurology clinics, emergency departments, and outpatient settings

Coding Complexity

High Complexity

This diagnosis requires careful attention to:

  • Comprehensive clinical documentation
  • Accurate code selection based on clinical criteria
  • Proper exclusion considerations
  • Specialty-specific coding guidelines

Documentation

Documentation Templates

Billing Information

Billing Considerations

  • Ensure proper documentation for billing
  • Verify code specificity requirements
  • Check for any additional codes needed
  • Review payer-specific guidelines

Common Issues

  • Insufficient clinical documentation
  • Incorrect code selection
  • Missing supporting diagnoses
  • Timing and frequency documentation

Frequently Asked Questions

What are the documentation requirements?

Document patient history, clinical findings, and treatment details.

What are the billing considerations?

Ensure accurate coding to reflect the specific type of herpes simplex infection.