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v1.0.0
ICD-10 Guide
ICD-10 CodesA66.1

A66.1

Primary genital syphilis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A66.1 is a billable code used to indicate a diagnosis of primary genital syphilis.

Key Diagnostic Point:

Primary genital syphilis is the initial stage of syphilis infection caused by the bacterium Treponema pallidum. This stage is characterized by the presence of a single or multiple painless ulcers, known as chancres, typically located on the genitalia, anus, or mouth. The chancres appear approximately 3 weeks after exposure to the bacterium and can last for 3 to 6 weeks if untreated. In addition to the local lesions, primary syphilis may also present with regional lymphadenopathy. The disease is primarily transmitted through sexual contact, including vaginal, anal, and oral sex. Geographic distribution of syphilis varies, with higher prevalence rates in urban areas and among certain populations, including men who have sex with men (MSM). Endemic areas include sub-Saharan Africa, parts of Asia, and some regions in the Americas. Early diagnosis and treatment with appropriate antibiotics, typically penicillin, are crucial to prevent progression to secondary syphilis and other complications.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between primary, secondary, and tertiary syphilis stages
  • Understanding the clinical presentation and documentation requirements
  • Awareness of co-infections and their impact on coding
  • Navigating the nuances of sexual health terminology

Audit Risk Factors

  • Inadequate documentation of clinical findings
  • Failure to specify the stage of syphilis
  • Misclassification of syphilis type
  • Lack of supporting lab results

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical notes on symptoms, history of exposure, and laboratory results.

Common Clinical Scenarios

Patients presenting with genital ulcers, lymphadenopathy, or atypical rashes.

Billing Considerations

Consideration of co-infections with HIV or other STIs is crucial for accurate coding.

Dermatology

Documentation Requirements

Photographic evidence of lesions, detailed descriptions of skin findings.

Common Clinical Scenarios

Patients with skin lesions that may be confused with other dermatological conditions.

Billing Considerations

Differentiating syphilitic lesions from other sexually transmitted infections or dermatological disorders.

Coding Guidelines

Inclusion Criteria

Use A66.1 When
  • According to the ICD
  • CM guidelines, A66
  • 1 should be used when the diagnosis of primary genital syphilis is confirmed through clinical evaluation and laboratory testing

Exclusion Criteria

Do NOT use A66.1 When
  • Exclusion criteria include other sexually transmitted infections that may present similarly

Related CPT Codes

86592CPT Code

Syphilis serology test

Clinical Scenario

Used to confirm diagnosis of primary genital syphilis.

Documentation Requirements

Document the reason for testing and results.

Specialty Considerations

Infectious disease specialists should ensure comprehensive STI screening.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of syphilis stages, improving data accuracy and facilitating better tracking of disease prevalence and treatment outcomes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of syphilis stages, improving data accuracy and facilitating better tracking of disease prevalence and treatment outcomes.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of syphilis stages, improving data accuracy and facilitating better tracking of disease prevalence and treatment outcomes.

Resources

Clinical References

  • •
    CDC Syphilis Fact Sheet

Coding & Billing References

  • •
    CDC Syphilis Fact Sheet

Frequently Asked Questions

What are the common symptoms of primary genital syphilis?

Common symptoms include the appearance of one or more painless ulcers on the genital area, along with swollen lymph nodes in the groin.