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ICD-10 Guide
ICD-10 CodesA69.21

A69.21

Meningitis due to Lyme disease

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A69.21 is a billable code used to indicate a diagnosis of meningitis due to lyme disease.

Key Diagnostic Point:

Meningitis due to Lyme disease is a rare but serious complication of Lyme borreliosis, an infectious disease caused by the spirochete Borrelia burgdorferi, which is transmitted to humans through the bite of infected Ixodes ticks. The condition is characterized by inflammation of the protective membranes covering the brain and spinal cord, leading to symptoms such as severe headache, fever, neck stiffness, and altered mental status. Lyme meningitis typically occurs in the later stages of Lyme disease, often presenting weeks to months after the initial tick bite. Diagnosis is confirmed through clinical evaluation, serological testing for antibodies against Borrelia, and sometimes lumbar puncture to analyze cerebrospinal fluid (CSF). Geographic distribution of Lyme disease is primarily in the northeastern, north-central, and Pacific coastal regions of the United States, with endemic areas also found in parts of Europe and Asia. Awareness of Lyme meningitis is crucial for timely diagnosis and treatment, as early intervention with appropriate antibiotics can lead to favorable outcomes.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Requires knowledge of Lyme disease epidemiology and clinical presentation.
  • Differentiation from other types of meningitis can be challenging.
  • Documentation must clearly link the diagnosis to the clinical findings.
  • Potential for misclassification with other spirochetal infections.

Audit Risk Factors

  • Inadequate documentation linking symptoms to Lyme disease.
  • Failure to provide serological test results.
  • Misdiagnosis or coding of other types of meningitis.
  • Lack of clarity in the clinical narrative regarding tick exposure.

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical history, laboratory results, and treatment plans.

Common Clinical Scenarios

Patients presenting with neurological symptoms after a known tick exposure.

Billing Considerations

Ensure that all relevant diagnostic tests are documented to support the diagnosis.

Neurology

Documentation Requirements

Neurological examination findings, imaging studies, and CSF analysis.

Common Clinical Scenarios

Patients with acute onset of meningitis symptoms and a history of Lyme disease.

Billing Considerations

Document any differential diagnoses considered and ruled out.

Coding Guidelines

Inclusion Criteria

Use A69.21 When
  • Follow the official ICD
  • CM coding guidelines, ensuring that the diagnosis is supported by clinical documentation
  • 21 should be used when meningitis is specifically attributed to Lyme disease, and other causes of meningitis have been ruled out

Exclusion Criteria

Do NOT use A69.21 When
No specific exclusions found.

Related CPT Codes

87493CPT Code

Borrelia burgdorferi antibody test

Clinical Scenario

Used to confirm Lyme disease in patients presenting with meningitis symptoms.

Documentation Requirements

Document the reason for testing and the patient's clinical presentation.

Specialty Considerations

Infectious disease specialists should ensure comprehensive testing for Lyme disease.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of Lyme disease-related conditions, improving the accuracy of epidemiological data and treatment outcomes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of Lyme disease-related conditions, improving the accuracy of epidemiological data and treatment outcomes.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of Lyme disease-related conditions, improving the accuracy of epidemiological data and treatment outcomes.

Resources

Clinical References

  • •
    CDC Lyme Disease Information

Coding & Billing References

  • •
    CDC Lyme Disease Information

Frequently Asked Questions

What are the symptoms of meningitis due to Lyme disease?

Symptoms include severe headache, fever, neck stiffness, and altered mental status, often occurring weeks after a tick bite.

How is Lyme meningitis diagnosed?

Diagnosis is made through clinical evaluation, serological testing for Borrelia antibodies, and analysis of cerebrospinal fluid.