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ICD-10 Guide
ICD-10 CodesA81.1

A81.1

Rabies virus encephalitis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A81.1 is a billable code used to indicate a diagnosis of rabies virus encephalitis.

Key Diagnostic Point:

Rabies virus encephalitis is a severe viral infection of the central nervous system (CNS) caused by the rabies virus, a member of the Lyssavirus genus. The disease typically follows an incubation period of 1 to 3 months after exposure, often through bites from infected animals. Initial symptoms may include fever, malaise, and headache, which can progress to neurological manifestations such as confusion, agitation, hallucinations, and paralysis. The hallmark of rabies encephalitis is the rapid progression to severe neurological impairment, including hydrophobia, aerophobia, and ultimately coma and death if not treated promptly. Diagnosis is primarily clinical, supported by history of exposure and laboratory tests, including PCR for rabies virus in saliva or cerebrospinal fluid. Vaccination status is critical; post-exposure prophylaxis (PEP) with rabies vaccine and rabies immune globulin is effective if administered before the onset of symptoms. Once clinical symptoms appear, the prognosis is poor, with a near 100% fatality rate. Understanding the clinical presentation and timely intervention is essential for managing this life-threatening condition.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Requires detailed patient history regarding exposure to rabies.
  • Differentiation from other viral encephalitides.
  • Documentation of vaccination status is crucial.
  • Potential for rapid clinical deterioration complicates coding.

Audit Risk Factors

  • Inadequate documentation of exposure history.
  • Failure to document vaccination status.
  • Misdiagnosis or coding of similar encephalitis types.
  • Lack of supporting laboratory results.

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Thorough documentation of exposure history, vaccination status, and clinical symptoms.

Common Clinical Scenarios

Patients presenting with neurological symptoms after animal bites.

Billing Considerations

Ensure all relevant lab results and clinical observations are documented to support coding.

Neurology

Documentation Requirements

Detailed neurological examination findings and progression of symptoms.

Common Clinical Scenarios

Patients with acute neurological decline and suspected viral encephalitis.

Billing Considerations

Document differential diagnoses and rationale for coding A81.1.

Coding Guidelines

Inclusion Criteria

Use A81.1 When
  • According to ICD
  • 10 coding guidelines, A81
  • 1 should be used when there is clear documentation of rabies virus infection with neurological involvement

Exclusion Criteria

Do NOT use A81.1 When
  • Exclusion criteria include other viral encephalitides unless rabies is confirmed

Related CPT Codes

87491CPT Code

Rabies virus detection, PCR

Clinical Scenario

Used when testing for rabies virus in suspected cases.

Documentation Requirements

Document the reason for testing and clinical symptoms.

Specialty Considerations

Infectious disease specialists should ensure thorough documentation of exposure history.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of rabies virus encephalitis, improving the accuracy of epidemiological data and enhancing the ability to track and manage cases effectively.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of rabies virus encephalitis, improving the accuracy of epidemiological data and enhancing the ability to track and manage cases effectively.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of rabies virus encephalitis, improving the accuracy of epidemiological data and enhancing the ability to track and manage cases effectively.

Resources

Clinical References

  • •
    CDC Rabies Information

Coding & Billing References

  • •
    CDC Rabies Information

Frequently Asked Questions

What is the importance of vaccination status in coding A81.1?

Vaccination status is critical as it influences the management of the patient and the coding process. It helps determine whether post-exposure prophylaxis was administered and impacts the clinical outcome.