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ICD-10 Guide
ICD-10 CodesB08.21

B08.21

Exanthema subitum [sixth disease] due to human herpesvirus 6

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B08.21 is a billable code used to indicate a diagnosis of exanthema subitum [sixth disease] due to human herpesvirus 6.

Key Diagnostic Point:

Exanthema subitum, commonly known as sixth disease, is a viral infection primarily affecting infants and young children, typically between the ages of 6 months and 2 years. It is caused by human herpesvirus 6 (HHV-6), which is a member of the herpesvirus family. The condition is characterized by a sudden high fever lasting 3 to 5 days, followed by a distinctive rash that appears as the fever subsides. The rash usually starts on the trunk and then spreads to the face and extremities, presenting as small, pink spots that may be slightly raised. While the fever can be quite high, the illness is generally self-limiting and resolves without complications. However, in some cases, febrile seizures may occur due to the rapid rise in temperature. Diagnosis is primarily clinical, based on the characteristic fever and rash pattern, and is often confirmed through serological testing for HHV-6. Treatment is supportive, focusing on fever management and hydration. Vaccination against HHV-6 is not currently available, making awareness and early recognition of the disease crucial for effective management.

Code Complexity Analysis

Complexity Rating: Low

Low Complexity

Complexity Factors

  • Clear clinical presentation with distinct symptoms
  • Well-defined age group affected
  • Limited differential diagnoses
  • No specific laboratory tests required for diagnosis

Audit Risk Factors

  • Misdiagnosis with other viral exanthems
  • Inadequate documentation of fever duration
  • Failure to note the age of the patient
  • Lack of follow-up documentation

Specialty Focus

Medical Specialties

Pediatrics

Documentation Requirements

Detailed history of fever and rash, including onset and duration.

Common Clinical Scenarios

Infants presenting with high fever followed by rash.

Billing Considerations

Ensure documentation reflects the age of the child and any associated symptoms.

Family Medicine

Documentation Requirements

Comprehensive patient history and physical examination findings.

Common Clinical Scenarios

Parents reporting sudden fever and rash in young children.

Billing Considerations

Document any parental concerns regarding febrile seizures.

Coding Guidelines

Inclusion Criteria

Use B08.21 When
  • According to ICD
  • 10 guidelines, B08
  • 21 should be used when the condition is confirmed as exanthema subitum due to HHV
  • It is important to document the clinical presentation and any associated symptoms accurately

Exclusion Criteria

Do NOT use B08.21 When
No specific exclusions found.

Related CPT Codes

99213CPT Code

Established patient office visit, Level 3

Clinical Scenario

Used for follow-up visits for children diagnosed with B08.21.

Documentation Requirements

Document history of present illness, physical exam findings, and any management plans.

Specialty Considerations

Pediatricians should ensure thorough documentation of symptoms and parental education.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of viral infections, improving data accuracy and facilitating better tracking of disease prevalence and outcomes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of viral infections, improving data accuracy and facilitating better tracking of disease prevalence and outcomes.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of viral infections, improving data accuracy and facilitating better tracking of disease prevalence and outcomes.

Resources

Clinical References

  • •
    CDC - Sixth Disease (Exanthema Subitum)

Coding & Billing References

  • •
    CDC - Sixth Disease (Exanthema Subitum)

Frequently Asked Questions

What age group is most affected by Exanthema subitum?

Exanthema subitum primarily affects infants and young children, typically between 6 months and 2 years of age.