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ICD-10 Guide
ICD-10 CodesB16.0

B16.0

Acute hepatitis B with delta-agent

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B16.0 is a billable code used to indicate a diagnosis of acute hepatitis b with delta-agent.

Key Diagnostic Point:

Acute hepatitis B with delta-agent is a viral infection of the liver caused by the hepatitis B virus (HBV) in conjunction with the hepatitis D virus (HDV), also known as the delta agent. This condition is characterized by the presence of both viruses, which can lead to more severe liver disease than infection with HBV alone. Transmission occurs primarily through contact with infectious body fluids, such as blood, semen, or vaginal secretions. High-risk populations include intravenous drug users, men who have sex with men, and individuals with multiple sexual partners. Acute hepatitis B with delta-agent can present with symptoms such as jaundice, fatigue, abdominal pain, and elevated liver enzymes. Chronic management may involve antiviral therapy, monitoring liver function, and regular screening for liver complications, including cirrhosis and hepatocellular carcinoma. The presence of the delta agent complicates the clinical course and management of hepatitis B, often leading to a more aggressive disease progression and a higher risk of liver-related complications.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Co-infection with two viruses (HBV and HDV)
  • Variability in clinical presentation and severity
  • Need for specific laboratory tests to confirm diagnosis
  • Potential for rapid progression to chronic liver disease

Audit Risk Factors

  • Inadequate documentation of co-infection status
  • Failure to document laboratory confirmation of HDV
  • Misclassification of acute vs. chronic hepatitis
  • Lack of detailed treatment plans in medical records

Specialty Focus

Medical Specialties

Gastroenterology

Documentation Requirements

Detailed history of liver disease, laboratory results, and treatment plans.

Common Clinical Scenarios

Patients presenting with jaundice, elevated liver enzymes, or complications from hepatitis.

Billing Considerations

Ensure documentation reflects the severity of liver disease and any co-morbid conditions.

Infectious Disease

Documentation Requirements

Comprehensive patient history, risk factors for transmission, and response to antiviral therapy.

Common Clinical Scenarios

Patients with acute hepatitis symptoms and a history of high-risk behaviors.

Billing Considerations

Document any co-infections and the patient's vaccination status against hepatitis A and B.

Coding Guidelines

Inclusion Criteria

Use B16.0 When
  • According to ICD
  • 10 coding guidelines, B16
  • 0 should be used when there is a confirmed diagnosis of acute hepatitis B with delta
  • Documentation must support the diagnosis, including laboratory confirmation of both HBV and HDV

Exclusion Criteria

Do NOT use B16.0 When
  • Exclusion criteria include cases where only HBV or HDV is present without the other

Related CPT Codes

86803CPT Code

Hepatitis B surface antigen (HBsAg) test

Clinical Scenario

Used to confirm diagnosis of hepatitis B infection.

Documentation Requirements

Document the reason for testing and results.

Specialty Considerations

Gastroenterology may require additional tests for liver function.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of hepatitis conditions, including the ability to differentiate between acute and chronic infections and co-infections, improving the accuracy of patient records and treatment plans.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of hepatitis conditions, including the ability to differentiate between acute and chronic infections and co-infections, improving the accuracy of patient records and treatment plans.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of hepatitis conditions, including the ability to differentiate between acute and chronic infections and co-infections, improving the accuracy of patient records and treatment plans.

Resources

Clinical References

  • •
    CDC Hepatitis B Information

Coding & Billing References

  • •
    CDC Hepatitis B Information

Frequently Asked Questions

What is the difference between hepatitis B and hepatitis D?

Hepatitis B is a viral infection that can occur alone, while hepatitis D requires the presence of hepatitis B to replicate. Co-infection with both can lead to more severe liver disease.