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v1.0.0
ICD-10 Guide
ICD-10 CodesB27.09

B27.09

Gammaherpesviral mononucleosis with other complications

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B27.09 is a billable code used to indicate a diagnosis of gammaherpesviral mononucleosis with other complications.

Key Diagnostic Point:

Gammaherpesviral mononucleosis is primarily caused by infections with gammaherpesviruses, notably Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6). This condition is characterized by symptoms such as fever, lymphadenopathy, and pharyngitis, similar to classic infectious mononucleosis. However, the presence of 'other complications' indicates additional clinical manifestations that may arise, such as splenomegaly, hepatitis, or neurological symptoms. Diagnosis typically involves serological testing for specific antibodies, such as heterophile antibodies, and PCR testing to detect viral DNA. Treatment is generally supportive, focusing on symptom relief, but antiviral medications like acyclovir may be indicated in severe cases or for immunocompromised patients. The complexity of this code arises from the need to accurately document the complications and the specific viral etiology, which can vary significantly among patients.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Variety of potential complications that must be documented
  • Differentiation between gammaherpesvirus infections and other viral infections
  • Need for precise serological and PCR testing results
  • Potential overlap with other ICD-10 codes for viral infections

Audit Risk Factors

  • Inadequate documentation of complications
  • Failure to specify the viral etiology
  • Incorrect coding of related symptoms or conditions
  • Lack of supporting lab results

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical notes on symptoms, lab results, and treatment plans.

Common Clinical Scenarios

Patients presenting with fever, fatigue, and lymphadenopathy requiring differential diagnosis.

Billing Considerations

Ensure all complications are documented and linked to the primary diagnosis.

Hematology

Documentation Requirements

Complete blood counts and any relevant hematological findings.

Common Clinical Scenarios

Patients with splenomegaly or cytopenias associated with viral infections.

Billing Considerations

Document any hematological abnormalities that may arise as complications.

Coding Guidelines

Inclusion Criteria

Use B27.09 When
  • Follow official ICD
  • CM coding guidelines, ensuring that all complications are documented
  • Include specific lab results and clinical findings to support the diagnosis

Exclusion Criteria

Do NOT use B27.09 When
No specific exclusions found.

Related CPT Codes

86790CPT Code

EBV antibody test

Clinical Scenario

Used to confirm EBV infection in suspected cases of mononucleosis.

Documentation Requirements

Document the reason for testing and results.

Specialty Considerations

Infectious disease specialists should ensure comprehensive testing.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of gammaherpesviral infections, improving the accuracy of data collection and reimbursement processes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of gammaherpesviral infections, improving the accuracy of data collection and reimbursement processes.

Reimbursement & Billing Impact

reimbursement processes.

Resources

Clinical References

  • •
    CDC - Epstein-Barr Virus

Coding & Billing References

  • •
    CDC - Epstein-Barr Virus

Frequently Asked Questions

What are the common complications associated with gammaherpesviral mononucleosis?

Common complications include splenomegaly, hepatitis, and neurological symptoms. Accurate documentation of these complications is essential for proper coding.