ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesB27.10

B27.10

Cytomegaloviral mononucleosis without complications

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B27.10 is a billable code used to indicate a diagnosis of cytomegaloviral mononucleosis without complications.

Key Diagnostic Point:

Cytomegaloviral mononucleosis is an infectious disease caused by the cytomegalovirus (CMV), a member of the herpesvirus family. It is characterized by symptoms similar to those of infectious mononucleosis, including fever, fatigue, sore throat, and lymphadenopathy. Unlike Epstein-Barr virus (EBV) mononucleosis, CMV mononucleosis can occur in immunocompetent individuals but is more commonly seen in immunocompromised patients. Diagnosis is typically made through serological testing, which detects CMV-specific IgM and IgG antibodies, or through PCR testing to identify viral DNA. The absence of complications, such as hepatitis or pneumonitis, distinguishes this code from other related codes. Treatment primarily focuses on supportive care, as antiviral therapy is generally reserved for severe cases or immunocompromised patients. The prognosis is generally good for healthy individuals, with most recovering fully without long-term effects.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiation from other viral infections like EBV
  • Need for serological testing and interpretation
  • Potential for misdiagnosis in immunocompromised patients
  • Documentation of absence of complications

Audit Risk Factors

  • Inadequate documentation of symptoms
  • Failure to specify the absence of complications
  • Misinterpretation of serological test results
  • Incorrect coding due to overlap with EBV mononucleosis

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical history, serological test results, and symptomatology.

Common Clinical Scenarios

Patients presenting with fever, fatigue, and lymphadenopathy.

Billing Considerations

Consideration of immunocompromised status and potential complications.

Primary Care

Documentation Requirements

Thorough patient history and physical examination findings.

Common Clinical Scenarios

Young adults presenting with mononucleosis-like symptoms.

Billing Considerations

Differentiation from EBV and other viral infections.

Coding Guidelines

Inclusion Criteria

Use B27.10 When
  • According to ICD
  • 10 coding guidelines, B27
  • 10 should be used when a patient presents with cytomegaloviral mononucleosis without any documented complications
  • Coders should ensure that the clinical documentation supports the diagnosis and that there is clear evidence of the absence of complications

Exclusion Criteria

Do NOT use B27.10 When
No specific exclusions found.

Related CPT Codes

86710CPT Code

Cytomegalovirus antibody test

Clinical Scenario

Used to confirm CMV infection in patients presenting with mononucleosis symptoms.

Documentation Requirements

Document the reason for testing and the results.

Specialty Considerations

Infectious disease specialists may require additional serological tests.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of CMV infections, improving the accuracy of data collection and reimbursement processes. B27.10 provides a clear distinction between cases with and without complications, which is essential for appropriate management and treatment.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of CMV infections, improving the accuracy of data collection and reimbursement processes. B27.10 provides a clear distinction between cases with and without complications, which is essential for appropriate management and treatment.

Reimbursement & Billing Impact

reimbursement processes. B27.10 provides a clear distinction between cases with and without complications, which is essential for appropriate management and treatment.

Resources

Clinical References

  • •
    CDC - Cytomegalovirus (CMV)

Coding & Billing References

  • •
    CDC - Cytomegalovirus (CMV)

Frequently Asked Questions

What are the common symptoms of cytomegaloviral mononucleosis?

Common symptoms include fever, fatigue, sore throat, and swollen lymph nodes. Some patients may also experience muscle aches and headaches.

How is cytomegaloviral mononucleosis diagnosed?

Diagnosis is typically made through serological testing for CMV antibodies and PCR testing for viral DNA, along with clinical evaluation.

What is the treatment for cytomegaloviral mononucleosis?

Treatment is primarily supportive, focusing on symptom relief. Antiviral medications may be used in severe cases or for immunocompromised patients.