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ICD-10 Guide
ICD-10 CodesB27.11

B27.11

Cytomegaloviral mononucleosis with polyneuropathy

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B27.11 is a billable code used to indicate a diagnosis of cytomegaloviral mononucleosis with polyneuropathy.

Key Diagnostic Point:

Cytomegaloviral (CMV) mononucleosis is a viral infection caused by the cytomegalovirus, which is a member of the herpesvirus family. It often presents with symptoms similar to those of infectious mononucleosis, including fever, fatigue, sore throat, and lymphadenopathy. In cases where polyneuropathy is present, patients may experience weakness, numbness, or pain due to nerve damage. CMV is particularly concerning in immunocompromised individuals, such as those with HIV/AIDS or organ transplant recipients. Diagnosis typically involves serological testing for CMV-specific IgM and IgG antibodies, as well as PCR testing to detect viral DNA. Treatment primarily focuses on supportive care, but antiviral medications such as ganciclovir or foscarnet may be indicated in severe cases or for immunocompromised patients. The presence of polyneuropathy complicates the clinical picture, necessitating a multidisciplinary approach for management and rehabilitation.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiation between CMV and other viral infections causing mononucleosis.
  • Need for comprehensive documentation of neurological symptoms.
  • Potential for co-infections or underlying immunocompromised states.
  • Variability in clinical presentation and laboratory findings.

Audit Risk Factors

  • Inadequate documentation of neurological symptoms.
  • Failure to document serological test results.
  • Misclassification of CMV infection severity.
  • Inconsistent coding of co-existing conditions.

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed history of symptoms, laboratory test results, and treatment plans.

Common Clinical Scenarios

Patients presenting with mononucleosis-like symptoms and confirmed CMV infection.

Billing Considerations

Consideration of immunocompromised status and potential complications.

Neurology

Documentation Requirements

Neurological examination findings, diagnostic imaging, and treatment response.

Common Clinical Scenarios

Patients with polyneuropathy symptoms following CMV infection.

Billing Considerations

Assessment of nerve conduction studies and potential need for rehabilitation.

Coding Guidelines

Inclusion Criteria

Use B27.11 When
  • Follow ICD
  • CM guidelines for coding infectious diseases and neurological conditions
  • Ensure accurate documentation of both the viral infection and the neurological manifestations
  • Include any relevant laboratory findings and treatment plans

Exclusion Criteria

Do NOT use B27.11 When
No specific exclusions found.

Related CPT Codes

87556CPT Code

Cytomegalovirus (CMV) DNA, qualitative or quantitative

Clinical Scenario

Used to confirm CMV infection in patients with mononucleosis symptoms.

Documentation Requirements

Document the reason for testing and results.

Specialty Considerations

Infectious disease specialists may order this test more frequently.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of conditions like CMV mononucleosis with polyneuropathy, improving the accuracy of patient records and treatment plans.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of conditions like CMV mononucleosis with polyneuropathy, improving the accuracy of patient records and treatment plans.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of conditions like CMV mononucleosis with polyneuropathy, improving the accuracy of patient records and treatment plans.

Resources

Clinical References

  • •
    CDC - Cytomegalovirus (CMV) Infection

Coding & Billing References

  • •
    CDC - Cytomegalovirus (CMV) Infection

Frequently Asked Questions

What are the common symptoms of cytomegaloviral mononucleosis?

Common symptoms include fever, fatigue, sore throat, swollen lymph nodes, and in some cases, neurological symptoms such as weakness or numbness.