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ICD-10 Guide
ICD-10 CodesB27.19

B27.19

Cytomegaloviral mononucleosis with other complication

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B27.19 is a billable code used to indicate a diagnosis of cytomegaloviral mononucleosis with other complication.

Key Diagnostic Point:

Cytomegaloviral (CMV) mononucleosis is a viral infection caused by the cytomegalovirus, which is a member of the herpesvirus family. This condition is characterized by symptoms similar to those of infectious mononucleosis, including fever, fatigue, sore throat, and lymphadenopathy. In cases classified under B27.19, the infection is complicated by additional factors such as hepatitis, pneumonia, or neurological manifestations. CMV is particularly concerning in immunocompromised individuals, such as those with HIV/AIDS, organ transplant recipients, or patients undergoing chemotherapy. Diagnosis typically involves serological tests to detect CMV-specific IgM and IgG antibodies, as well as PCR testing to identify viral DNA in blood or other body fluids. Antiviral treatments, such as ganciclovir or foscarnet, may be employed in severe cases or in immunocompromised patients to manage the infection and its complications. Understanding the nuances of this condition is crucial for accurate coding and effective patient management.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between CMV mononucleosis and other viral infections.
  • Identifying and documenting specific complications associated with CMV.
  • Understanding the patient's immunocompromised status and its implications.
  • Navigating serological and PCR testing results for accurate diagnosis.

Audit Risk Factors

  • Inadequate documentation of complications.
  • Failure to specify the patient's immunocompromised status.
  • Misinterpretation of serological test results.
  • Inconsistent coding of related conditions.

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical notes on symptoms, lab results, and treatment plans.

Common Clinical Scenarios

Patients presenting with mononucleosis-like symptoms and a history of immunosuppression.

Billing Considerations

Ensure all complications are documented and linked to the primary diagnosis.

Hematology/Oncology

Documentation Requirements

Comprehensive records of the patient's cancer treatment and any related immunosuppression.

Common Clinical Scenarios

Oncology patients developing CMV infections post-chemotherapy.

Billing Considerations

Highlight the relationship between chemotherapy and increased risk of CMV complications.

Coding Guidelines

Inclusion Criteria

Use B27.19 When
  • Follow the official ICD
  • CM coding guidelines, ensuring that all documentation supports the diagnosis of CMV mononucleosis with complications
  • Include specific details about the complications and the patient's clinical status

Exclusion Criteria

Do NOT use B27.19 When
No specific exclusions found.

Related CPT Codes

87530CPT Code

Cytomegalovirus (CMV) DNA, qualitative, PCR

Clinical Scenario

Used to confirm CMV infection in symptomatic patients.

Documentation Requirements

Document the reason for testing and clinical findings.

Specialty Considerations

Infectious disease specialists should ensure comprehensive documentation of symptoms.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of CMV infections, improving the accuracy of data collection and reimbursement processes. B27.19 provides a clear distinction for cases with complications, which is crucial for patient management and epidemiological tracking.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of CMV infections, improving the accuracy of data collection and reimbursement processes. B27.19 provides a clear distinction for cases with complications, which is crucial for patient management and epidemiological tracking.

Reimbursement & Billing Impact

reimbursement processes. B27.19 provides a clear distinction for cases with complications, which is crucial for patient management and epidemiological tracking.

Resources

Clinical References

  • •
    CDC - Cytomegalovirus (CMV) Infection

Coding & Billing References

  • •
    CDC - Cytomegalovirus (CMV) Infection

Frequently Asked Questions

What are the common complications associated with CMV mononucleosis?

Common complications include hepatitis, pneumonia, and neurological issues such as encephalitis. These complications can significantly impact the patient's health and require careful management.