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ICD-10 Guide
ICD-10 CodesB27.82

B27.82

Other infectious mononucleosis with meningitis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B27.82 is a billable code used to indicate a diagnosis of other infectious mononucleosis with meningitis.

Key Diagnostic Point:

Infectious mononucleosis is primarily caused by the Epstein-Barr virus (EBV), but other viral agents such as cytomegalovirus (CMV) and human immunodeficiency virus (HIV) can also lead to similar presentations. When infectious mononucleosis is complicated by meningitis, it indicates an inflammatory response in the meninges, which can manifest with symptoms such as fever, headache, neck stiffness, and altered mental status. Diagnosis typically involves a combination of clinical evaluation, serological tests for EBV and CMV, and lumbar puncture to analyze cerebrospinal fluid (CSF) for signs of infection and inflammation. Antiviral treatments may be indicated, particularly in cases caused by CMV or HIV, and supportive care is essential for managing symptoms. The presence of meningitis complicates the clinical picture, requiring careful monitoring and management to prevent potential neurological sequelae.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between viral causes of mononucleosis
  • Need for lumbar puncture and CSF analysis
  • Potential overlap with other viral infections
  • Documentation of neurological symptoms

Audit Risk Factors

  • Inadequate documentation of neurological symptoms
  • Failure to document the results of lumbar puncture
  • Misidentification of the viral cause
  • Lack of clarity in the clinical rationale for the diagnosis

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical history, laboratory results, and treatment plans.

Common Clinical Scenarios

Patients presenting with fever, lymphadenopathy, and neurological symptoms.

Billing Considerations

Ensure all viral testing results are documented and correlate with clinical findings.

Neurology

Documentation Requirements

Neurological examination findings, imaging results, and CSF analysis.

Common Clinical Scenarios

Patients with altered mental status and signs of meningitis.

Billing Considerations

Document any neurological deficits and their progression.

Coding Guidelines

Inclusion Criteria

Use B27.82 When
  • According to ICD
  • 10 guidelines, B27
  • 82 should be used when there is a confirmed diagnosis of infectious mononucleosis with accompanying meningitis
  • Documentation must support the diagnosis, including clinical symptoms and laboratory findings

Exclusion Criteria

Do NOT use B27.82 When
No specific exclusions found.

Related CPT Codes

62270CPT Code

Lumbar puncture

Clinical Scenario

When CSF analysis is required for diagnosis.

Documentation Requirements

Document indication for lumbar puncture and results.

Specialty Considerations

Ensure that the procedure is linked to the diagnosis of meningitis.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of infectious mononucleosis and its complications, improving the accuracy of data collection and reimbursement processes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of infectious mononucleosis and its complications, improving the accuracy of data collection and reimbursement processes.

Reimbursement & Billing Impact

reimbursement processes.

Resources

Clinical References

  • •
    CDC Viral Meningitis Information

Coding & Billing References

  • •
    CDC Viral Meningitis Information

Frequently Asked Questions

What are the common causes of infectious mononucleosis with meningitis?

The most common cause is Epstein-Barr virus (EBV), but cytomegalovirus (CMV) and HIV can also lead to this condition.

How is infectious mononucleosis with meningitis diagnosed?

Diagnosis is made through clinical evaluation, serological tests for viral infections, and lumbar puncture to analyze cerebrospinal fluid.

What treatments are available for this condition?

Treatment may include antiviral medications for specific viral infections and supportive care to manage symptoms.