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ICD-10 Guide
ICD-10 CodesB34.4

B34.4

Herpesviral encephalitis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B34.4 is a billable code used to indicate a diagnosis of herpesviral encephalitis.

Key Diagnostic Point:

Herpesviral encephalitis is a severe neurological condition primarily caused by the herpes simplex virus (HSV), most commonly HSV-1. It is characterized by inflammation of the brain, leading to symptoms such as fever, headache, seizures, confusion, and altered mental status. The condition can progress rapidly, resulting in significant morbidity and mortality if not treated promptly. Diagnosis typically involves a combination of clinical evaluation, imaging studies such as MRI, and laboratory tests including PCR (polymerase chain reaction) to detect HSV DNA in cerebrospinal fluid (CSF). Early recognition and treatment with antiviral medications, particularly acyclovir, are crucial for improving outcomes. The condition can occur in both immunocompetent and immunocompromised individuals, but the latter group is at a higher risk for severe manifestations. Complications may include long-term neurological deficits, seizures, and even death, underscoring the importance of timely intervention.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between HSV types (1 vs. 2) and their clinical implications.
  • Need for precise documentation of symptoms and diagnostic tests.
  • Potential for co-infections or other neurological conditions complicating the diagnosis.
  • Variability in clinical presentation among different patient populations.

Audit Risk Factors

  • Inadequate documentation of clinical symptoms.
  • Failure to document the results of diagnostic tests.
  • Misclassification of the type of herpes virus involved.
  • Inconsistent coding of associated neurological conditions.

Specialty Focus

Medical Specialties

Neurology

Documentation Requirements

Detailed neurological examination findings, imaging results, and laboratory test outcomes.

Common Clinical Scenarios

Patients presenting with acute onset of seizures, altered mental status, or focal neurological deficits.

Billing Considerations

Documentation must clearly indicate the relationship between symptoms and the diagnosis of herpesviral encephalitis.

Infectious Disease

Documentation Requirements

History of exposure, immunocompromised status, and response to antiviral therapy.

Common Clinical Scenarios

Patients with recurrent infections or those with a history of HSV presenting with neurological symptoms.

Billing Considerations

Consideration of differential diagnoses and co-infections is critical.

Coding Guidelines

Inclusion Criteria

Use B34.4 When
  • According to ICD
  • 10 guidelines, B34
  • 4 should be used when herpesviral encephalitis is confirmed through clinical and laboratory findings
  • It is important to document the specific type of herpes virus when applicable and to follow the guidelines for coding associated conditions

Exclusion Criteria

Do NOT use B34.4 When
No specific exclusions found.

Related CPT Codes

87491CPT Code

Herpes simplex virus (HSV) DNA, PCR

Clinical Scenario

Used when testing CSF for HSV in suspected cases of herpesviral encephalitis.

Documentation Requirements

Document the clinical indication for the test and results.

Specialty Considerations

Neurology and Infectious Disease specialists should ensure accurate interpretation of results.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of herpesviral encephalitis, improving the accuracy of data collection and reimbursement processes. It has also facilitated better tracking of epidemiological trends related to herpes infections.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of herpesviral encephalitis, improving the accuracy of data collection and reimbursement processes. It has also facilitated better tracking of epidemiological trends related to herpes infections.

Reimbursement & Billing Impact

reimbursement processes. It has also facilitated better tracking of epidemiological trends related to herpes infections.

Resources

Clinical References

  • •
    CDC - Herpes Simplex Virus

Coding & Billing References

  • •
    CDC - Herpes Simplex Virus

Frequently Asked Questions

What are the common symptoms of herpesviral encephalitis?

Common symptoms include fever, headache, seizures, confusion, and altered mental status. Patients may also exhibit focal neurological deficits depending on the areas of the brain affected.