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v1.0.0
ICD-10 Guide
ICD-10 CodesB39.3

B39.3

Histoplasmosis capsulati, unspecified

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B39.3 is a billable code used to indicate a diagnosis of histoplasmosis capsulati, unspecified.

Key Diagnostic Point:

Histoplasmosis capsulati is a fungal infection caused by the organism Histoplasma capsulatum, which is commonly found in soil enriched with bird or bat droppings. The infection can be asymptomatic or can present with a range of symptoms, including fever, cough, fatigue, and chest pain. In immunocompromised patients, such as those with HIV/AIDS, cancer, or those on immunosuppressive therapy, histoplasmosis can lead to severe pulmonary disease or disseminated infection affecting multiple organ systems. Diagnosis is typically made through clinical evaluation, serological tests, and culture of the organism. Treatment often involves antifungal medications such as itraconazole or amphotericin B, especially in severe cases. The unspecified designation indicates that the specific manifestation of histoplasmosis is not documented, which can complicate treatment and management strategies.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in clinical presentation and severity of the disease.
  • Need for thorough documentation to differentiate from other fungal infections.
  • Potential for misclassification in immunocompromised patients.
  • Lack of specificity in the unspecified code, which may lead to coding errors.

Audit Risk Factors

  • Inadequate documentation of clinical findings.
  • Failure to specify immunocompromised status.
  • Misuse of unspecified codes leading to potential denials.
  • Inconsistent coding practices across different healthcare settings.

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed patient history, clinical findings, and treatment response.

Common Clinical Scenarios

Patients presenting with respiratory symptoms and a history of exposure to endemic areas.

Billing Considerations

Consideration of immunocompromised status and potential for disseminated disease.

Pulmonology

Documentation Requirements

Pulmonary function tests, imaging studies, and response to antifungal therapy.

Common Clinical Scenarios

Patients with chronic cough and lung nodules on imaging.

Billing Considerations

Differentiation from other pulmonary infections and conditions.

Coding Guidelines

Inclusion Criteria

Use B39.3 When
  • Follow official ICD
  • 10 coding guidelines, ensuring accurate documentation of the patient's clinical status, including any immunocompromised conditions

Exclusion Criteria

Do NOT use B39.3 When
  • Exclude other fungal infections that may present similarly

Related CPT Codes

87449CPT Code

Fungal culture

Clinical Scenario

Used when a fungal infection is suspected and requires confirmation.

Documentation Requirements

Document the reason for the culture and any prior treatments.

Specialty Considerations

Infectious disease specialists may order this more frequently.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of histoplasmosis, improving the ability to track and manage cases effectively. However, the unspecified code can lead to challenges in treatment planning and reimbursement.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of histoplasmosis, improving the ability to track and manage cases effectively. However, the unspecified code can lead to challenges in treatment planning and reimbursement.

Reimbursement & Billing Impact

reimbursement.

Resources

Clinical References

  • •
    CDC - Histoplasmosis

Coding & Billing References

  • •
    CDC - Histoplasmosis

Frequently Asked Questions

What are the common symptoms of histoplasmosis?

Common symptoms include fever, cough, fatigue, chest pain, and in severe cases, respiratory distress or systemic symptoms.

How is histoplasmosis diagnosed?

Diagnosis is made through clinical evaluation, serological tests, and culture of the organism from respiratory secretions or tissue samples.

What treatments are available for histoplasmosis?

Treatment options include antifungal medications such as itraconazole for mild cases and amphotericin B for severe cases.