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v1.0.0
ICD-10 Guide
ICD-10 CodesB45.7

B45.7

Cryptococcosis, unspecified

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B45.7 is a billable code used to indicate a diagnosis of cryptococcosis, unspecified.

Key Diagnostic Point:

Cryptococcosis is a fungal infection caused by the Cryptococcus species, primarily Cryptococcus neoformans and Cryptococcus gattii. This infection is particularly significant in immunocompromised individuals, such as those with HIV/AIDS, organ transplant recipients, or patients undergoing immunosuppressive therapy. The fungus is typically acquired through inhalation of airborne spores found in soil, particularly in areas with bird droppings. Symptoms can range from mild respiratory issues to severe neurological complications, including meningitis. Diagnosis is often made through culture, serological tests, or imaging studies. Treatment typically involves antifungal medications, with amphotericin B and flucytosine being the first-line therapies for severe cases, while fluconazole may be used for less severe infections. The unspecified nature of this code indicates that the specific site of infection or severity is not documented, which can complicate treatment and management decisions.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in clinical presentation and severity of cryptococcosis.
  • Need for precise documentation of immunocompromised status.
  • Differentiation from other fungal infections.
  • Potential for co-infection with other pathogens.

Audit Risk Factors

  • Inadequate documentation of immunocompromised status.
  • Failure to specify the site of infection.
  • Misclassification of the severity of the infection.
  • Lack of supporting lab results or imaging studies.

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed patient history, including immunocompromised status and clinical presentation.

Common Clinical Scenarios

Patients presenting with respiratory symptoms or neurological signs in the context of immunosuppression.

Billing Considerations

Ensure clear documentation of diagnostic tests and treatment plans.

Pulmonology

Documentation Requirements

Pulmonary function tests, imaging studies, and detailed symptom descriptions.

Common Clinical Scenarios

Patients with chronic cough, fever, and chest pain.

Billing Considerations

Document any co-existing lung conditions that may affect treatment.

Coding Guidelines

Inclusion Criteria

Use B45.7 When
  • Follow the official ICD
  • CM coding guidelines, ensuring accurate documentation of the patient's condition, including any underlying immunocompromising factors

Exclusion Criteria

Do NOT use B45.7 When
  • Exclude codes for other specified cryptococcosis when using B45

Related CPT Codes

87481CPT Code

Cryptococcus neoformans antigen test

Clinical Scenario

Used to confirm diagnosis in suspected cases.

Documentation Requirements

Document the reason for the test and results.

Specialty Considerations

Infectious disease specialists should ensure accurate interpretation of results.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of cryptococcosis, improving the ability to track and manage this infection in various patient populations, particularly those who are immunocompromised.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of cryptococcosis, improving the ability to track and manage this infection in various patient populations, particularly those who are immunocompromised.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of cryptococcosis, improving the ability to track and manage this infection in various patient populations, particularly those who are immunocompromised.

Resources

Clinical References

  • •
    CDC Fungal Diseases

Coding & Billing References

  • •
    CDC Fungal Diseases

Frequently Asked Questions

What is the primary cause of cryptococcosis?

Cryptococcosis is primarily caused by the inhalation of spores from the Cryptococcus fungus, commonly found in soil and bird droppings.

Who is most at risk for developing cryptococcosis?

Individuals who are immunocompromised, such as those with HIV/AIDS, organ transplant recipients, or patients on immunosuppressive therapy, are at the highest risk.