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v1.0.0
ICD-10 Guide
ICD-10 CodesC22.0

C22.0

Billable

Liver cell carcinoma

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 C22.0 is a billable code used to indicate a diagnosis of liver cell carcinoma.

Key Diagnostic Point:

Liver cell carcinoma (HCC) is the most common primary malignancy of the liver, often arising in the context of chronic liver disease, particularly cirrhosis. It is characterized by the uncontrolled proliferation of hepatocytes, which can lead to significant morbidity and mortality. The condition is frequently associated with underlying liver diseases such as hepatitis B and C infections, alcoholic liver disease, and non-alcoholic fatty liver disease (NAFLD). Patients with cirrhosis are at a markedly increased risk for developing HCC, with surveillance recommended for those with cirrhosis using imaging techniques and serum alpha-fetoprotein (AFP) levels. Elevated AFP levels can serve as a biomarker for diagnosis and monitoring of HCC progression. Treatment options for liver cell carcinoma may include surgical resection, liver transplantation, and locoregional therapies, depending on the stage of the disease and the underlying liver function. The prognosis for patients with HCC is often poor, particularly in advanced stages, making early detection and intervention critical.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Differentiation between primary and secondary liver cancers
  • Association with cirrhosis and other liver diseases
  • Need for accurate staging and grading of the tumor
  • Interpretation of AFP levels and their clinical significance

Audit Risk Factors

  • Inaccurate documentation of cirrhosis status
  • Failure to document AFP levels and their significance
  • Misclassification of tumor stage or grade
  • Inadequate documentation of treatment plans and outcomes

Specialty Focus

Medical Specialties

Hepatology

Documentation Requirements

Detailed history of liver disease, imaging results, and AFP levels.

Common Clinical Scenarios

Patients with chronic hepatitis or cirrhosis presenting with new-onset abdominal pain or weight loss.

Billing Considerations

Ensure documentation reflects the relationship between cirrhosis and HCC, including surveillance protocols.

Oncology

Documentation Requirements

Staging information, treatment plans, and response to therapy.

Common Clinical Scenarios

Patients undergoing treatment for HCC, including surgical interventions or chemotherapy.

Billing Considerations

Accurate staging is crucial for treatment decisions and prognosis.

Coding Guidelines

Inclusion Criteria

Use C22.0 When
  • According to ICD
  • 10 guidelines, C22
  • 0 should be used when the diagnosis of liver cell carcinoma is confirmed
  • It is important to document the presence of cirrhosis or other liver diseases as they significantly impact treatment and prognosis

Exclusion Criteria

Do NOT use C22.0 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

47133CPT Code

Liver transplantation

Clinical Scenario

Performed for patients with HCC meeting transplant criteria.

Documentation Requirements

Document the diagnosis, staging, and transplant eligibility criteria.

Specialty Considerations

Hepatology and transplant surgery must coordinate documentation.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of liver cancers, improving the accuracy of data collection and reimbursement processes. C22.0 provides a clear distinction for liver cell carcinoma, enhancing clinical understanding and treatment planning.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of liver cancers, improving the accuracy of data collection and reimbursement processes. C22.0 provides a clear distinction for liver cell carcinoma, enhancing clinical understanding and treatment planning.

Reimbursement & Billing Impact

reimbursement processes. C22.0 provides a clear distinction for liver cell carcinoma, enhancing clinical understanding and treatment planning.

Resources

Clinical References

  • •
    American Cancer Society - Liver Cancer

Coding & Billing References

  • •
    American Cancer Society - Liver Cancer

Frequently Asked Questions

What is the significance of elevated AFP levels in liver cell carcinoma?

Elevated AFP levels can indicate the presence of liver cell carcinoma and are used for diagnosis, monitoring treatment response, and assessing recurrence risk.