ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesD46.9

D46.9

Billable

Myelodysplastic syndrome, unspecified

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D46.9 is a billable code used to indicate a diagnosis of myelodysplastic syndrome, unspecified.

Key Diagnostic Point:

Myelodysplastic syndromes (MDS) are a group of hematological disorders characterized by ineffective hematopoiesis, leading to blood cell dysplasia and cytopenias. MDS can arise de novo or secondary to prior chemotherapy or radiation therapy. The unspecified designation indicates that the specific subtype of MDS has not been determined, which can complicate treatment and prognosis. Patients may present with symptoms such as fatigue, weakness, recurrent infections, and bleeding tendencies due to low blood cell counts. The risk of progression to acute myeloid leukemia (AML) is a significant concern, as MDS can evolve into more aggressive forms of blood cancer. Surveillance is critical, involving regular blood counts and monitoring for signs of transformation. The management of MDS may include supportive care, growth factor therapy, and in some cases, stem cell transplantation. Accurate coding is essential for appropriate treatment planning and insurance reimbursement, as well as for tracking disease outcomes in clinical practice.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in clinical presentation and symptoms
  • Need for precise documentation of blood counts and dysplastic features
  • Potential for progression to acute leukemia requiring careful monitoring
  • Differentiation from other hematological disorders

Audit Risk Factors

  • Inadequate documentation of blood counts and dysplastic features
  • Failure to specify the subtype of MDS when known
  • Lack of follow-up documentation indicating disease progression
  • Inconsistent coding practices across different providers

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed blood count results, bone marrow biopsy findings, and treatment history.

Common Clinical Scenarios

Diagnosis of MDS following abnormal blood tests, monitoring for progression to AML.

Billing Considerations

Ensure clarity in documentation regarding the subtype of MDS and any associated complications.

Oncology

Documentation Requirements

Comprehensive treatment plans, response to therapy, and follow-up assessments.

Common Clinical Scenarios

Management of patients with MDS undergoing chemotherapy or stem cell transplantation.

Billing Considerations

Document any transformation to acute leukemia and the rationale for treatment decisions.

Coding Guidelines

Inclusion Criteria

Use D46.9 When
  • Follow the official ICD
  • CM coding guidelines, ensuring accurate documentation of the patient's clinical status, treatment history, and any relevant laboratory findings

Exclusion Criteria

Do NOT use D46.9 When
  • Exclude conditions that are not classified as MDS

Related ICD-10 Codes

Related CPT Codes

85027CPT Code

Complete blood count (CBC) with differential

Clinical Scenario

Used to monitor blood counts in patients with MDS.

Documentation Requirements

Document the reason for the CBC and any abnormal findings.

Specialty Considerations

Hematologists should ensure regular CBCs are performed to track disease progression.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of myelodysplastic syndromes, improving the accuracy of data collection and reimbursement processes. This specificity aids in better tracking of disease outcomes and treatment efficacy.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of myelodysplastic syndromes, improving the accuracy of data collection and reimbursement processes. This specificity aids in better tracking of disease outcomes and treatment efficacy.

Reimbursement & Billing Impact

reimbursement processes. This specificity aids in better tracking of disease outcomes and treatment efficacy.

Resources

Clinical References

  • •
    Myelodysplastic Syndromes Foundation

Coding & Billing References

  • •
    Myelodysplastic Syndromes Foundation

Frequently Asked Questions

What is the significance of coding D46.9?

Coding D46.9 indicates an unspecified myelodysplastic syndrome, which is crucial for tracking patient outcomes and ensuring appropriate management. Accurate coding helps in understanding the disease's behavior and potential progression.